Relationship Between Expression Of Thrombin In Human Brain And ICP, Prognosis After Intracerebral Hemorrhage

Objective Being cell toxicity factor, thrombin plays an important role in brainedema formation after intracerebral hemorrhage (ICH) was determined by lots ofanimal studies. But nowadays, there are still no evidence in clinical trial. So, weinvestigated the expression of thrombin in human brain after ICH and its relationshipbetween intracranial pressure (ICP) and prognosis of patients with ICH.Methods The expression of thrombin was examined with immunohistochemicalmethod in 35 cases of ICH, the relationship to ICP and prognosis was alsocomparatively analyzed.Results Positive staining with thrombin was either moderately or stronglyobserved in all tissues, the expression of thrombin averaged 0.5686±0.2739 showsmoderate positive correlation to ICP (ICP_1d 309.71±89.89 mmH₂o r_s1=0.640 p＜0.05;ICP_3d 317.71±103.95 mmH₂or_s2=0.639 p＜0.05;ICP_7d 275.00±85.57 mmH₂o r_s3=0.529 p＜0.05), andmoderate negative correlation to GOS averaged 2.91±1.31 (r_s4=-0.800 p＜0.05).Conclusion Thrombin plays an important role in brain edema formation afterICH, and is associated with ICP and outcome in patients. This study providesevidence that brain edema after ICH might be reduced or inhibited by anti-thrombintherapy.