Clinical Study Of Lamotyigine In Epileptic Children

Objective To evaluate the efficacy and safety of lamotyigine in monotherapy and concomitant therapy for epilepsy in childhood.Methods This study collected 84 patients of epilepsy aged from 8 to 12 years old. The patients who have no AEDs enter monotherapy group, and the patients who are treated by no more than 2 drugs enter concomitant therapy group by strict standard.1. Review period Collect detailed information of disease type, frequency, head CT or MRI, EEG and other lab data through medical record enrollments. Usage of drug is recorded carefully. We hand out observation questionnaire to patients to get further information of epilepsy in childhood.2.Adding quantity period 8-12weeks. The target dose is 2-5mg/kg/d. Monotherapy: original dosage of lamotyigine is 0.3mg/kg/d in the first two weeks, 0.5mg/kg/d in the next two weeks, and since then 0.5mg/kg/d increase every one or two weeks. The concomitant therapy: (l)Add-on valproicacid. Original dosage of lamotyigine is 0.15mg/kg/d in the first two weeks, 0.3mg/kg/d in the next two weeks, and since then 0.5mg/kg/d increase every one or two weeks. (2)Concomitant enzyme-inducing antiepileptic drugs. Original dosage of lamotyigine is 0.6mg/kg/d in the first two weeks, 1.0mg/kg/d in the next two weeks, and since then 1.0mg/kg/d increase every one or two weeks3. Stabilization period We observe the patients who keep on target dose for 12 weeks. We visit the patients every month from Review period to the end of stabilization period, and countercheck blood routine test, urine routine test, liver function, renal function and EEG. The type and dose of AEDs used of the concomitant therapy group is invariable.Results There were 78 children patients of epilepsy, who were treated with Lamotrigine or additive drug. There were 22 patients in the single drug group. The total effective rate is 76.92 %. 11 subjects were simple partial seizure, effective rate is 90.91 %; 34 subjects were complex partial seizure, effective rate is 73.53 %; 18 subjects were rigidity clonic seizure, effective rate is 77.78%; 4 subjects were tonic seizure, effective rate is 75.00%; 4 subjects were myoclonic seizure, effective rate is 75.00%; 7 subjects were Lennox Symptom, effective rate is 71.43%. We compared the therapeutic effects of the single drug group and additive drug group by analysis of variance. The results indicated that there was no significant differences between the two groups. There was less side effects after the children patient taking Lamotrigine. Only 11 subjects had dizzy, headache, unsteadiness of walking, bad appetite, sleepness, but these symptoms were light. These symptoms can be disappeared after treating .They didn't affect the therapy. All children were observed the appearance of efflorescence.Conclusion Lamotyigine in monotherapy and concomitant therapy for seizure is effective , relatively safe and with less side-effect.