Clinical Significance Of Heparanase And Basic Fibroblast Growth Factor Expressions In Cervical Cancer

Clinical significance of heparanase and basic fibroblast growth factor expressions in cervicalcancerObjective: To investigate the expressions of heparanase(HPA) and basic fibroblast growth factor(bFGF) in chronic cervicitis, cervical intraepithelial neoplasia(CIN) and cervical cancer, and toexplore their roles in the pathogenesis of cervical cancers by analyzing the relationship with theclinicalpathological features.Methods: Immunohistochemical stain PV-9000 method was used to detect the expressions of HPAand bFGF in 48 cases of cervical cancer tissues, 39 cases of cervical intraepithelial neoplasia ,and 20cases of chronic cervicitis tissues were taken as control.The levels of HPA and bFGF in differentcervical lesion tissues and their relations with clinicalpathological parameters were analyzed. Dataanalysis was carried by chis-square test.Results: 1. The results of immunohistochemical stain disclosed the major localizations of HPAwere in the cytoplasm and(or) the cellular membrane of malignant cells and the color was buffy orbrownish-black. While the results of immunohistochemical stain disclosed the major localizations ofbFGF were in the cytoplasm and the color was yellow or buffy. 2. HPA was not expressed in chroniccervicitis and CINⅠ, The positive rates of HPA expression in CINⅡ,CINⅢand cervical cancer were10.00%, 21.05% and 54.17%; The positive rates of bFGF expression in chronic cervicitis,CINⅠ,CINⅡ,CINⅢand cervical cancer were 20.00%, 40.00%, 30.00%, 31.58% and 64.58%.3.There wereno significant differences of HPA and bFGF in between chronic cervicitis and cervical intraepithelialneoplasia (P＞0.05); 3.There were no significant differences of HPA and bFGF expressing in the differ-rent grades of cervical intraepithelial neoplasia(P＞0.05); 4. The different expressions of HPA andbFGF in chronic cervicitis and cervical cancer had statistical significance as well as their different ex-pressions in CIN and cervical cancer. 5.In cervical cancer tissues,the expressions of HPA and bFGFwere both positively associated with clinical- pathological parameters: clinical stage, tumor size andlymphatic metastasis(P＜0.05); but were no relation with age, histological classification and histolo-gical grade (P＞0.05).6.Positive correlation between the expression of HPA and bFGF was observed incervical cancer(P＜0.05).Conclusion:1.The expressions of HPA and bFGF tended to increase along with pathogenetic conditionprogression, suggested that HPA and bFGF possibly played an important role in the genesis of cervicalcancer. 2. The expressions of HPA and bFGF had no statistical relation with age, which suggestedthat HPA and bFGF were not major fators to promoting the occurrence of more young women with ce-rvical cancers. 3. The expressions of HPA and bFGF had significant relation with clinical stage, tumorsize and lymphatic metastasis,in addition the expression of HPA was positive correlation with bFGF,which suggested HPA may play an important role in the development, invasion and metastasis of cer-vical cancer together with bFGF.HPA may be an important referenced index of predicting biologicalbehavior and a valuable target of the treatment of cervical cancer.