Expression And Clinical Significance Of IGF-1R In Human Primary Uveal Malignant Melanoma

Objective To detect the expression of IGF-1R in uveal malignant melanoma and to investigate the relationship between IGF-1R expression and prognosis in uveal malignant melanoma. To explore the effect of IGF-1R on the prognosis evaluation of epithelial uveal malignant melanoma.Methods The expressions of IGF-1R were detected by immunohistochemistry from 41 cases of uveal malignant melanoma (13 cases of spindle cell type,14 cases of mixed cell type,14 cases of epithelial cell type).The correlations between IGF-1R expressions and clinicopathological parameters were assessed by x~2 test. The overall survival rate was determined by Kaplan-Meier.High risk factors of primary uveal malignant melanoma patients' survival time were analysed by Cox's proportional hazard regression model.Results Of 41 cases of uveal malignant melanoma, IGF-1R positive expressions were present diffusely in the cytoplasm of cancer cells in 28 cases (28/41=68.3%). The expression was significantly associated with the cell type, the height and largest basal diameter of tumor (P<0.05) , but unrelated with sexes and ages of the patients, and involvement of ciliary body by x~2 test. It also showed the tendency of an shorter survival rate in patients either with IGF-1R positive expression ,or larger basal diameter, or higher tumor, or epithelial tumor by Kaplan-Meier survival analysis. It suggested IGF-1R be an independent prognostic factor by multivariate analysis (P = 0.030), but weaker than such currently used prognostic parameters as tumor cell type (P=0.001, Exp(B)=8. 380). In multivariate Cox regression analysis of melanoma-specific survival, the hazard ratios were 1.938 for expression IGF-1R, 8.380 for the presence of epithelioid cells, 1.393 for the tumor height≥8mm.Conclusion IGF-1R express in uveal malignant melanoma. The expression of IGF-1R may be a prognosis factor in human uveal malignant melanoma. It may be an important factor to evaluate the prognosis and clinical curative effect of human uveal malignant melanoma.