Changes Of Hepatocyte Growth Factor Contents In Serum Of The Patients With SIRS And The Relationship With The Renal Function

Objectives: We explored the clinical value of hepatocyte growth factor (HGF)to diagnose renal dysfunction in patients with SIRS,through comparing serum contents of HGF in patients with and without acute renal injury.Methods: Enzyme-linked immunoadsordent assay(ELISA) was used to detect the levels of HGF and TNF-αin serum of 32 patients with SIRS (experimental group)and 15 healthy subjects( control group),then the differences of HGF and TNF-αconcentrations between two groups were analyzed.According to the endogenenous creatinine clearance rate(Ccr), 32 patients were subdivided into four groups and analyzed the differences of HGF and TNF-αconcentrations again.Results: 1.There were no differences in age, score of APACHEⅡ, concentrations of CRP between the every group of patients (p>0.05). 2. Serum concentrations of HGF and TNF-αin patients with SIRS were significantly higher than those in the controls ( p<0.05 ) . 3. Serum concentrations of HGF in mild acute renal injury were significantly increased,while the levels of TNF-αshowed significantly difference between mild- moderate acute renal injury and severe ones(p<0.05).4.The level of HGF and TNF-αnegatively correlated with Ccr(r=-0.930, -0.816, p<0.01, respectively).Conclusions: 1.Patients with SIRS had significantly high levels of HGF and TNF-αin serum.The concentrations of TNF-αwere increased in patients,especially in those with severe acute renal injury,and correlated with outcome of the patients, so we concluded that TNF-αreflected severity of the illness.3. HGF was negatively correlated with Ccr and obviously increased in mild acute renal injury ,it suggested that HGF may play an important role in pathogenesis of acute renal injury and mediate early events in renal repair. 4.No doubt, HGF is a simple ,early and prospective marker for renal function in SIRS.