Studies On The Pharmaceutical Of Gutong Capsule

GuT0ng Capsule is a compound preparation, It is made on basis of a clinical prescription, It consists of Rhizoma Drynariae, Radix Paeoniae Alba and so on. GuTong Capsule is beneficial for treating Osteoarthritis and has the effect of tonifying kidney and removing blood stasis to promote circulation, dispelling cold pathogen and driving away the damp pathogen. This subjet has studied on its preparation process and quality standards.1. Study on the preparationAccording properties of the herbs of the prescription and the need in theclinic, the capsules are selected as the dosage form of the drug. The optimum extraction condition was studied by orthogonal test regarding naringin content of the main herb drug drynarina and extraction rate of the Gutong capsule as the indicating standards. And getting the conclusion that the optimum extraction process was reliable: used the crude cutting drug size, boiling 3 times; 1.5h, 1h, 0.5h each time, the amount of water was 12, 10, 8 times of the amount of the crude drug amount. Regarding the oil-containing ratio as the index, The best enveloping technology is that the proption of oil andβ-CD is 1:4,β-cyclodextrin to water is l:15,enveloping temperature is 30℃, the enveloping time is 2 hours. The optimum extraction method is selected by orthogonal test as naringin content of the main herb drug drynarina and extraction rate of the Gutong capsule for the indicating standards. Getting the conclusion that the optimum extraction process was reliable: putting the concentrated solution in the 60℃water for heating, adding 1% chitosan solution which is 10% of the amount of the concentrated solution. stirring the solution for 20min and the speed of stirring is 100r/min.The observation of the effect for the property of the extracting-power with different auxiliary component is done by contrast experiment, the study of moulding preparation shows that when the proportion of extracting-power and microcrystal-cellulose and starch is 5:0.5:0.5 the moisture-absorption of the extracting-power can be lowered and has a good fluidity mixing the extracting-power and the auxiliary component,the critical contrasting humidity is about 67.5%, divide one capsule equally, The package was 0.48 gram for each capsule.2. Study on quality standardRhizoma Chuanxiong and Radix Angelicae Pubescentis were indentified by TLC. The separation of the stains is apparent, the negative constrast is not disturbed, Using HPLC to determine Naringin content, according to the methological study, this method is reliable and can be used to measure the content of preparations.