Expression Of The BRCA1,Bad,Rb In Breast Benign And Maligant Lesions

Objective:To investigate the expression of BRCA11,Bad,Rb in breast benign and maligant lesions and the correlation to cancer development.Method: immunohistochemical staining method of SP were used to detect the BRCA1,Bad,Rb gene expressions in 20 usual ductal hyperplasia,28 atypical ductal hyperplasia and 25 breast cancer tissue.Resnlt:(1)immunohistochemical staining method of SP results revealed that when compared with the positive rates of usual ductal hyperplasia,atypical ductal hyperplasia and breast cancer were 5%(1/20),39.3%(11/28),76.0%(19/25) in BRCA1.The positive rates of BRCA1 in usual ductal hyperplasia and atypical ductal hyperplasia were significant(P＜0.01).The positive rates of BRCA1 in atypical ductal hyperplasia and breast cancer were significant(P＜0.01).The positive rates of BRCA1 in usual ductal hyperplasia and breast cancer were significant(P＜0.01).(2)The Bad positive rates were 15.0%(3/20),35.7%(10/28),72.0%(18/25)in usual ductal hyperplasia,atypical ductal hyperplasia and breast cancer respectively.The positive rates of Bad in usual ductal hyperplasia and atypical ductal hyperplasia were unsignificant(P＞0.05).The positive rates of Bad in atypical ductal hyperplasia and breast cancer were significant (P＜0.01).The positive rates of Bad in usual ductal hyperplasia and breast cancer were significant(P＜0.01).(3)The Rb positive rates were 75.0%(15/20),53.6%(15/28),16.0% (4/25)in usual ductal hyperplasia,atypical ductal hyperplasia and breast cancer respectively.The positive rates of Rb in usual ductal hyperplasia and atypical ductal hyperplasia were unsignificant(P＞0.05).The positive rates of Rb in atypical ductal hyperplasia and breast cancer were significant(P＜0.01).The positive rates of Rb in usual ductal hyperplasia and breast cancer were significant(P＜0.01)4.Expression of BRCA1, Bad and Rb were no relation in the breast disease.Conclusion:the abnormal expressions of BRCA1,Bad and Rb gene may be related to the deveiopment of breast cancinoma.