Expression Alteration Study Of Intestinal Tumor Related Genes In Hazak's Esophageal Cancer

Objective: To study the expression alteration of intestinal related genes in carcinogenesis of Hazak's esophageal cancer. Methods: The expression of these genes was detected in 20 cases of esophageal cancer tissues and tumor-adjacent normal tissues by the method of Reverse Transcription Polymerase Chain Reaction. Results: In detected oncogenes, the expression of Survivin gene increased in 10 cases compared with that in tumor-adjacent normal tissues within 20 cases; 7 cases show higher expression level for cdc42; The expression of tumor suppress genes does not show dramatic changes in all detected samples. There are 8 cases have increased expression level for MMP-7 that related with tumor metastasis. Conclusion: Changes of Survivin and Cdc42 gene expression indicate that they might play certain roles in carcinogenesis and progression of Hazak's esophageal cancer. The results of MMP-7 gene expression indicated that part of Hazak's esophageal cancer have metastasis inclination. The results that the expression level of all detected genes does not show dramatic change in a group of samples suggest that the specific mechanism may control the development for Hazak's esophageal cancer.