Clinicopathologic And Prognostic Analysis Of 127 Primary Vulvar And Vaginal Malignant Tumors

Objective: To summarize clinicopathologic features, surgery and follow-up information of patients with vulvar carcinoma (VC) and vaginal carcinoma (VaC) of our hospital in recent 6 years; to investigate characteristics of recurrence and metastasis of vulvar carcinoma and vaginal carcinoma. Methods: A retrospective analysis of 127 patients with primary invasive vulvar carcinoma or vaginal carcinoma treated at our hospital between 2001 and 2006 was conducted. The Cox proportional hazards model and Chi-Square test were used to assess independent variables as prognostic factors for treatment failure. Result: (1)clmical data:①The mean age of the 102 VC patients was 49.7 years old, while the mean age of the 25 VaC patients was 49.04 years old.②The number of VC patients with menopause was 57, while the number of VaC was 14.(2)Results of statistic analysis:①Pathological stage: Prognosis was much poorer in advanced stage for both of the VC and VaC patients (P<0.05 ) .②Tumor size: VC and VaC patients with tumors larger than 4cm in diameter had poorer prognosis (P<0.05) .③Vascular invasion: Prognosis was much poorer for patients with vascular invasion (P<0.05).④lymph node involvement: In all the 102 VC patients, 2 or more lymph node metastasis occurred in 23, and these patients had a significantly lower survival rate compared with those who did not occur or had only one lymph node involved(P<0.05).And so were the VaC patients.⑤Pathological type: VC patients with squamous-cell type hade better prognosis than those with non-squamous-cell type(P<0.05).⑥Length of the vagina involved: VaC patients with longer vagina involved had poorer progno-sis, which had statistic significance (P<0.05) .Conclusions: (1)Squamous-Cell type still accounts for significantly larger proportions in VC and VaC, while the proportions of other histological types remain the same. (2) Single-factor analysis indicated that FIGO stage, pathological type, tumor size, lymph node involvement and vascular invasion had independent prognostic significance in VC. And the FIGO stage, tumor size, lymph node involvement, length of the vagina involved and vascular invasion had independent prognostic significance in VaC. (3) Multiple-factor analysis indicated that FIGO stage, pathological type, lymph node involve-ment and vascular invasion had independent prognostic significance in VC.