Influencing Factors For Chronic Obstructive Pulmonary Disease Patients Complicated With Invasive Pulmonary Aspergillosis

Objectives: To investigate the influencing factors for chronic obstructive pulmonary disease (COPD) patients complicated with invasive pulmonary aspergillosis (IPA).Materials and Methods: 111 patients were enrolled in this study. 37 patients who suffered from COPD complicated with IPA served as case group, another 74 COPD patients without IPA as control group. The clinical data of those 111 patients were analysed retrospectively. The possible influencing factors were measured as followings: COPD course, concomitant diseases, duration in hospital, intensive care unit (ICU), smoking history, plasma albumin level, mechanical ventilation, invasive procedure, use of glucocortocoids and antibiotics. In univariate analysis, numerical variables were compared by t test (normal distribution) or Wilcoxon rank test (skewed distribution) and categorical variables by X~2 test. Those variables with P values less than 0.05 were analysed by binary Logistic regression model in multivariate analysis. Results: According to univariate analysis, the influencing factors for COPD patients complicated with IPA included: duration in hospital, ICU, smoking history, plasma albumin level, mechanical ventilation, invasive procedure, use of glucocortocoids and antibiotics. Multivariate analysis indicated that plasma albumin level, mechanical ventilation, invasive procedure, and use of glucocortocoids were main influencing factors for those patients.Conclusions: COPD patients complicated with IPA were influenced by many factors. The main influencing factors included: plasma albumin level, mechanical ventilation, invasive procedure, and use of glucocortocoids.