Influencing And Interaction Of C-reactive Protein And Cardiovascular Risk Factors On Hypertension

Objective: To explore the relationship between C-reactive protein , cardiovascular factors and hypertension, and the interaction of C-reactive protein and other cardiovascular risk factors on hypertension in Mongolian people, to provide a foundation for the prevention and control of hypertension and its further etiological studies.Methods: On the basis of a prevalence survey, 767 hypertensives and 762 normotensives aged =30 were selected as subjects to conduct case-control study. All these subjects were investigated for smoking cigarette, alcohol intake and the history of cardiovascular disease, and their body mass index (BMI), waist-hip ratio (WHR), plasma glucose, serum lipids, insulin and circulating levels of C-reactive protein were measured with standardized methods. All data were analyzed by using SPSS software on the computer. Single factor analysis and non-conditional multiple logistic analysis were used to analyse relationship between C-reactive protein and other vascular risk facors and hypertension. Interacton of C-reactive protein and other risk factors on hypertension was analysed by means of logistic model.Results : Alcohol drinking rate in cases was significantly higher than that in controls , and OR was 2.175(1.755-2.695), P<0.001) , after adjustment for other risk factors, OR was 2.068 (1.618-2.642) (P<0.001). Rate of family history for hypertension in cases was significantly higher than that in controls , and OR was 5.065 (3.592-7.142) ,P<0.001, OR was 4.658 (3.240-6.698) after adjustment for other risk factors. OR of persons with BMI≥24.0 was 2.81(2.22—3.56) compared with persons with BMK24.0, OR was 2.877(2.218-3.731)after adjustment for other facors . OR of persons with WHR≥0.9 was 1.68(1.36-2.08), OR was 1.330(1.050-1.680), after adjustment for other facors ,both P<0.001. Rates of high TG, high TC and high LDL-C in cases were significantly higher than that in controls, and OR was 2.346 (1.799-3.061), 1.601 (1.067-2.402) and 1.521(1.046-2.210), respectively . Only OR of TG had significant meaning after adjustment for other factors. Level of CRP (2.10±0.83 mg/L) in cases was significantly higher than that (1.80±0.77 mg/L) in controls. Subjects was divided into four groups according to level of CRP, OR values of three groups from low to high was 1.205(0.904-1.607), 1.803(1.353-2.404) and .2.621(1.956-3.511), respectively, compared to lowest level of CRP. OR values was 1.127(0.827-1.536), 1.303(0.949-1.790) and 1.501(1.074-2.098), respectively , after adjustment for other factors. There was a trend that risk of prevalence of hypertension was increasing with level of CRP( x _MH² =7.397, P=0.013). There was a significant interaction of CRP and smoking and insulin resistance on hypertension after adjustment for other risk factors, and RERI were 0.799(P<0.01) and 0.651(P<0.05).Conclusions: Alcohol drinking, overweight, obesity, hypertriglyceridemia and family history of hypertension were risk factors of hypertension in Mongolian; Level of CRP was related with hypertension. There was interaction between CRP and smoking and insulin resistance on hypertension.