Clinical Studies Of The Relationship Between Microalbuminuria And Platelet Activation In Essential Hypertensive Patients

Objective :To assess the relative role of microalbuminuria(MA) and the platelet activation factor CD62P,CD63 in essential hypertensionve patients.Methods:Our study population consisted of sixty cases of essential hypertensive patients (age 50～70 years, 35 males, 25 females) with negative routine urine testing and 18 normal individuals(age 50~65 years, 10 males, 8 females). Exclusion criteria were diabetes or secondary hypertension, severe cardiovascular and cerebrovascular disease, hepatic and renal disease, thrombus and bleeding disease, malignant tumor, treatment with aspirin and clopidogrel medicines which affect platelet activiation recently. Body mass index, fasting plasma glucose, total cholesterol, triglycerides, creatinine clearance, blood pressure , microalbuminuria and the platelet activation factor CD62P,CD63 were measured and compared respectively.Albuminuria≥30mg/L was defined as microalbuminuria (MA) and <30mg/L was defined as normo-microalbuminuria(NMA). According to albuminuria measured in first morning urine samples, essential hypertensive patients were classified into two groups: patients with MA and patients with NMA. The clinic characteristics of the study population and MA, CD62P and CD63 were statistically analysed.Results:1. Of the sixty essential hypertensive patients included in the study, MA was found in 28(0.46) patients, NMA was found in 32(0.54) patients. According to the 2004"The Guidelines For Prevention and treatment of Hypertension in China", 10 patients had isolated systolic hypertension (4 were MA, 6 were NMA) , 31 had 1 grade hypertension (8 were MA, 23 were NMA), 18 had 2 grade hypertension (15 were MA, 3 were NMA), and 1 had 3 grade hypertension (1 was MA). Of all the subjects, no differences were observed in terms of age, gender distribution, body mass index, fasting plasma glucose, total cholesterol, triglycerides and creatinine clearance.2. MA group had significant higher systolic pressure, diastolic pressure, mean arterial pressure(P<0.01), and level of the platelet activation factor CD62P,CD63 (P<0.05) as compared with NMA group and normal control group.3. Regression analysis showed that the occurrence of MA was correlated with the platelet activation factor CD62P,CD63 level(r=0.76,P<0.01;r=0.74,P<0.01)and the level of CD62P was correlated with CD63(r=0.74,P<0.01).Conclusions:Essential hypertensive patients with microalbuminuria show evidence of higher blood pressure and platelet activation, which may cause higher risk of cardiovascular complications.