| Objective:To explore the effect of Cardiovascular risk factors on target organ damage in hypertensive patients.Methods:3386 hypertensive patients in hospital were divided into 5 groups, based on the numbers of risk factors, the first group without risk factors (group A, n=346) and other four groups complicated with 1(group B, n=1086), 2(group C, n=1159), 3 (group D, n=593)and≧4(group E, n=202) risk factors.Results:(1)From group A to E, the left mean ventricular mass index (LVMI: g/㎡, 123.31±35.22, 135.39±34.74, 137.09±33.67, 143.86±36.09, 152.58±46.33 respectivel y, P<0.001) and the incidence of left ventricular hypertrophy (LVH: 42.8%, 64.4%, 67.7%, 73.5%, 75.2% respectively, P﹤0.01) significantly increased, so did the mean serum createnine (Cr:μmol/L, 92.06±28.35, 99.00±32.57, 102.12±34.38, 109.21±40.53, 114.51±44.07 respectively, P<0.01). (2) For each risk factor increased in the hypertensive patients(from group A to E), the incidence of coronary heart disease (CHD: 7.8%, 15.9%, 20.3%, 26.0%, 37.6% respectively, P < 0.001), cardia insufficiency(2.6%, 6.6%, 7.6%, 10.8%, 12.9% respectively, P < 0.001), cerebrovascular disease (CVD: 24.3%, 42.7%, 47.2%, 52.8%, 55.0% respectively, P<0.001)and renal functional lesion (3.5%, 7.7%, 8.9%, 14.7%, 21.3% respectively, P<0.001)significantly increased. (3)After adjusting for age and course of diseases, for each risk factor increased, the risk ratio(OR)for CHD, cardia insufficiency, CVD and renal functional lesion significantly increased up to 42.5%, 33.4%, 25.3%, 35.7% respectively, P<0.05. Both of age and pathoglycemia are correlated with cardiovascular disease. Smoking was one independent risk factor for the CHD, cardiac insufficiency and CVD; obesity was a significant risk factor for the CHD and cardiac insufficiency, but significantly decreased the risk of CVD up to 48%; blood lipid abnormity could significantly raise the risk of the CHD, cerebral arterial thrombosis and renal functional lesion, but reduce the risk of cerebral hemorrhage up to 36%.Conclusion :①Stroke was the major prognosis of hypertensive patients.②Cardiovascular risk factors have additive effect on target organ damage in hypertensive patients.③Obesity could reduce the risk for the cerebrovascular disease in hypertensive patients, blood lipid abnormity has different effect on cerebral arterial thrombosis and encephalorrhagia. Objective: To investigate the relationship between risk factors and the events of cardiovascular diseases (CVD) in hypertensive patients in hospital.Methods: 380 hypertensive patients in hospital were divided into two groups: the event group (n=159) and the non-event one (n=221), according to new CVD events during the follow up 5-10 years.Results: (1)The height sequence of CVD event was CVD(23%)﹥CHD(22%)﹥death(17%)﹥functional lesion (15%)﹥cardia insufficiency (12%)﹥T2DM(11%). (2) The mean numbers of CVD risk factors in the event group were significant higher than that in the non-event one (2.17±1.05 vs. 1.36±0.97, P﹤0.001). (3)The rate of eld, abnormal blood-lipid, pathoglycemia, smoking and early onset cardiovascular family history was significant higher in the event group than that in the non-event one. No significant difference of rate of obesity was found between two groups. (4)After adjusting for age, sex, course of diseases and pulse pressure, multivariates analysis showed that smoking, abnormal blood-lipid, pathoglycemia, early onset cardiovascular family history were the main risk factors of the new onset CVD event (OR: 2.23,1.84,2.04,4.17 respectively). (5) With increasing each risk factor, the risk ratio of new onset CVD event increased 46%.Conclusion: Cardiovascular risk factors have additive effect on cardiovascular event in hypertensive patients.
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