The Effect Of Intensive Insulin Treatment On Emotion In Type 2 Diabetic Patients

Objective The prevalence of comorbid depression people with type 2 diabetes mellitus(T2DM) is reportedly higher than in the general population. Some scholars think the change that lead to diabetes'pathophysiologic may be the important reason of depression. The outgrowth changes by diabetes included two side: one is disorder of blood glucose; the other is abnormality of neuroendocrine. Absolute or relative absence of insulin is the prime cause of diabetic glucose metabolism.So that, use insulin treatment not only rectify the glucose metabolism's disorder, but asle correct neurotransmitters'abnormality,promote neurons outgrowth and stop the base of pathophysiological of emotion disorder. The article compares depression before intensive insulin treatment with after in T2DM, meanwhile compare depression after intensive insulin treatment with after oral antihyperglycemic agents and the relation with thyroid hormone level. To study impact of intensive insulin treatment on emotion in diabetes patients. Methods Self-Rating Depression Scale was used to screen depression in patients with T2DM right away and after intensive insulin treatment. We tested all patient's thyroid hormone,FPG,2hPG,HbA1c at the same time. To compare befor treatment with after and to compare with oral antihyperglycemic agents. Fasting plasma glucose between 4.6 mmol/L and 6.1mmol/L, 2 hours postprandial glucose between 4.4 mmol/L and 8.0mmol/L. Data was count by t-test and rand sum test. Results Depression degree showed significantly difference befor and after insulin treatment(P<0.01), but oral antihyperglycemic agents showed no significantly difference befor and after treatment(P>0.05). T3,T4 were highter and TSH was lower in comorbid depression patients than no comorbid depression befor treatment (P<0.01). T3,T4 in both groups were reduced, depression groups showed significantly difference befor and after treatment,no depression groups showed no significantly difference befor and after treatment.TSH was reduced lightly, but showed no significantly difference. Depression index was negatively correlated with T3,T4, was positive correlation with TSH. A drop in depression index was positive correlation with T3,T4 (P<0.01).Conclusion Intensive insulin treatment could markedly improved depression status in diabetic patients and that was closely related with thyroid hormone level.