Diffusion and metastasis of tumors are the primary reason of death of patients who have got cancers. Recent researches have indicated that the dysfunction or down regulation of E-cadherin is related closely to the poorly differentiated, invasion and metastasis of tumor. Hypoxia is common in all solid tumors. The hypoxia-inducible factor-1α(HIF-1α) is the most important factor involved in the cellular response to hypoxia, a local tissue decrease in the oxygen concentration. Nowadays people have commenced to pay close attention to its role in cell adhesion with increasingly interest.To investigate whether expression of HIF-1αis relevant with down regulation of expression of E-cadherin or not, and their effects on biological behavior of bladder transitional cell carcinoma, we examined expressions of E-cadherin and HIF-1αin bladder transitional cell carcinoma by immunohistochemical assay.The results are as the followings:①There is a significant correlation between the expression of HIF-1αwith disease progress, pathological grades and clinic grades in bladder transitional cell carcinoma (p<0.05,p<0.05,p<0.05 respectively);②There is also a significant correlation between the expression of E-cadherin with disease progress, pathological grades and clinic grades in bladder transitional cell carcinoma (p<0.01,p<0.05,p<0.01 respectively);③It's negative correlation between the expression of E-cadherin and HIF-1αin bladder transitional cell carcinoma(p<0.01).Therefore, we think that overexpression of HIF-1αis related to down-regulation of E-cadherin in bladder transitional cell carcinoma, and that Co-detection of HIF-1αand E-cadherin may help estimate the malignency of bladder transitional cell carcinoma. Our results suggest that HIF-1α-E-cadherin may be possible candidates for molecular targeting in the future treatment of bladder transitional cell carcinoma.
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