The Study On Aerobic Exercise With Different Time Concerning Anti-senility

Exercise and training have been proved creating significant effect on fighting and delaying senility through tremendous research, though still the research related with anti-senility benefited from exercise is still at the stage of beginning. For some conflicting phenomenon emerging in senility trial, explanation convincing still has not been found, research and analysis concerned with relationship between exercise and senility is also relatively less, further study and development are still expected.Purpose: To establish rat model for senility research. Observe free radical metabolism and antioxidase system vitality changing in blood, brain tissue and skeletal muscle of the rats which have gone through regular aerobic exercise. To enlighten the effect on senility brought by exercising of different amount and capacity, and make a good foundation for continued exercise and senility research.Method: Randomly divided established senility model(employing female SD rats of three months)into four groups: control, exercising group of 0.5 h, 1.5 h, and 2h. After swimming training of 12 weeks, put to death and took blood, cerebrum, cerebellum, musculus quadriceps fexoris, and musculus soleus for antioxidase system vitality and free radical level testing. Testing Items include: SOD, GSH-px, CAT, H2O2.Result: As the experiment shows, regular aerobic exercise and training long period can result in increased GSH-px, and CAT vitality, in which the GSH-px acitivity of 1h exercising group and the CAT acitivity of 0.5h exercising group were mostly promoted ,and decreased MDA and H2O2 content in serum of senility rats, as a result, eliminating oxidative damage; it also enables increased SOD, GSH-px, and CAT vitality in cerebrum of senility rats, in which the acitivity of 1h and 0.5h exercising group was mostly promoted ,and reduces MDA content dramatically, while SOD vitality in cerebellum shows a trend of decline, however, MDA content is in accordance with the result in cerebrum, ie., being reduced considerably after swimming training. In addition, regular aerobic exercise and training long period can also develop SOD, GSH-px, and CAT vitality in musculus quadriceps fexoris of senility rats, in which the effect of 1h exercising group was inferor to other groups, reducing MDA content effectively, and lowering lipid peroxidation level. And within appropriate exercise capacity, it functions more in reducing oxyradical damage as time prolonging. likewise, same situation happened in soleus muscle of senility rats, while within appropriate exercise capacity, in which SOD of 1h exercising group was mostly increased, GSH-px of 2h exercising group was mostly increased and CAT was not obviously changed in each group . The effect of reducing free radical generating and improving clearance capacity was inferior to the former based on exercise capacity of same time.Conclusion: Aerobic exercise can develop antioxidase system vitality in the blood, tissue and organ of senility rat, meanwhile, eliminate free radical and peroxidation lipid product from damaging organism. Our research demonstrates that tissue variabilities are present in terms of effect on oxidase system and oxyradical in various tissue and organ brought by exercise, and different exercising time means different antioxidase activity, and within the range of aerobic exercise, it will be more effective in righting oxidative damage as exercise time prolonging.