Effects Of Fluoride On The Expression Of C-fos,c-jun In Fibroblasts

Extraperiosteal calcification and ossification plays an important role in the development of severe disabled skeletal fluorosis. We will focus our attention on the expression of c-fos and c-jun in fibroblast , which is the main type of cell exists in the extraperiosteal soft tissue including tendon and the point linking up the ligament. It is of interest to note that the relationship between expression of proto oncogenes c-fos, c-jun and osteogenetic function of fluoride-treated FB. Proto oncogenes are inducible transcriptional factors and regulate growth factors such as bFGF,TGF-β,Col I,c-myc and endothelin in cooperation with other transcriptional factors and play the key roles in cell proliferation, differentiation and signal transduction. The higher expression of c-fos and c-jun in fluoride-treated FB and OB were found in this study. It is possible that proto oncogenes have cooperated with fluoride in the inducible expression of cbfa1, OCN and bone derived growth factors in FB.