Serum SP-A,IL-8,hsCRP Levels In Patients With Chronic Obstructive Pulmonary Disease And Their Clinical Significance

ObjectiveTo know Surfactant proteins A(SP-A),Interleukin-8(IL-8),C-reactive proteins (CRP)levels and their clinical significance in patients with stable chronic obstructive pulmonary disease(COPD).MethodsA total of 54 stable COPD patients and 20 healthy controls were enrolled.All patients were measured body height and weight,recorded smoking pack-years and measured six-minutes walking test(6MWT).The British Medical Research Council (MRC)dyspnea scale was used to assess the degree of dyspnea and St.George's Respiratory Questionnaire(SGRQ).Patient's fasting venous blood were collected, and then centrifuged and reserved serum.The serum SP-A,IL-8,CRP levels in 54 stable COPD patients and 20 healthy controls were measured by enzyme-linked immunosorbent assay(ELISA)and linear correlation analysis were used to analysis the correlation between serum SP-A,IL-8 and pulmonary function,life quality,dyspnea,exercise capacity,nutritional status.Results1.The serum SP-A,IL-8,CRP levels in COPD patients(39.25±6.14pmol/l) (82.26±14.37pg/ml)(0.07±0.03mg/l)were significantly higher than those in the healthy controls(15.85±1.81 pmol/l),(26.28±3.09pg/ml),(0.02±0.01mg/l)(p＜0.01). The serum SP-A(49.7±7.05pmol/l),IL-8(110.9±16.56pg/ml),CRP(0.08±0.04mg/l) levels in smoking COPD patients were significantly higher than those in the nonsmoking controls(16.52±2.25 pmol/l,P＜0.05),(19.92±2.63pg/ml,P＜0.01),(0.05±0.02mg/l,P＜0.05).2.The serum IL-8,CRP levels in aggravate COPD patients(116.94±17.77pg/ml) (0.09±0.05mg/l)were significantly higher than those in the midrange controls (35.52±5.23pg/ml),(0.05±0.02mg/l),(P＜0.01).3.Linear correlation analysis showed that the serum SP-A,IL-8,CRP was negtively with Forced expiratory volume in one second(FEV1)(r=-0.273,-0.304,-0.435,P＜0.05),and positively with sympodrom scores of life quality(r=0.363,0.357,0.343,P＜0.05),and positively with total scores of SGRQ(r=0.3,0.371,0.491,P＜0.05).Conclusion1.The serum SP-A,IL-8,CRP levels in stable COPD patients were higher,It shows that stable COPD patients not only have aiway inflammation but have systemic inflammation.2.The serum SP-A,IL-8,CRP levels in smoking stable COPD patients were higher than nonsmoking controls.It shows that smoking maybe a reason of higher serum SP-A,IL-8,CRP levels.Smoking can cause lung injury,serum SP-A reflect increased alveolocapillary leakage and degee of lung injury,serum IL-8,CRP maybe correlate with degee of lung injury.3.The serum SP-A,IL-8,CRP levels in stable COPD patients were correlate with airflow limitation.and life quality.The serious is airflow limitation,the worst is life quality and the higher is serum SP-A,IL-8,CRP levels.It shows that airflow limitation.can affect systemic inflammation and life quality.