The Related Factors Between Liver Cirrhosis And Gallbladder Stone

Objective We retrospectively studied two hundred and thirty cirrhotic inpatients, aimed to evaluate the prevalence of gallstones and related risk factors in a large series of patients with cirrhosis.Methods Two hundred and thirty consecutive cirrhotic patients (29.57 Child A, 50 Child B and 40.43 Child C) hospitalized in the Department of liver transplantation of the first affiliated hospital of Xinjiang medical university, between January 2003 and January 2007,were included.liver function tests, coagulation function and abdominal B-ultrasonography were performed,all these patients were confirmed as suffering from liver cirrhosis. Aimed to evaluate the frequency of gallstones and study the relationship between gallstones and gender, age, previous alcohol abuse, Child-pugh, the inside diameter of portal vein,serum levels of albumin and total bilirubin, prothrombin time, and ascites. Results The overall prevalence of gallstones was 30.43%(70/230) in our cirrhotic patients,more higher than that of the control group(6.80%,17/250).Of the 230 study subjects ,17 of the 54 inpatients(31.48%) in the group of inside diameter of portal vein >13mm had gallstones,higer than that of the inside diameter of portal veinc13mm(30.11%), P> 0.5. The prevalence of gallstones significantly difference between Child's class A (17/68,14.71%) ,Child's class B(32/115,27.83%) and Child's class C (21/47,44.68%), P<0.05.Logistic regression analysis showed that the presence of gender and Child-pugh were the risk factors for the gallstones in patients with liver cirrhosis (OR=0.975,P=0.013 ; OR=2.112,P=0.033).No relationships with the factors for the prevalence of gallstones in liver cirrhosis, such as sex, previous alcohol abuse, serum levels of albumin,total bilirubin ,the inside diameter of portal vein ,prothrombin time or ascites were found. Disscussion Gallstones in our cirrhotic patients more prevalent than in general population.Sex,previous alcohol abuse, serum levels of albumin,total bilirubin ,the inside diameter of portal vein,prothrombin time or ascites did not influence in gallstones prevalence in our cirrhotic patients.Child-Pugh class and sex were the risk factors for the gallstones in patients with liver cirrhosis.The severity of liver disfunction may be associated with an in increased risk of gallstone formation. the patients with severe liver function is more likely to have gallstones. The destory effectivity of estrogenic hormone become lower in cirrhotic patients, the high content of estrogenic hormone to refrain the production of cholalic acid and influent evacuation in gall bladder and creat condition to form gallstone. So there is difference between male and female in the incidence rate of gallstone.