The Correlation Analysis Between Clinic-biological Characteristics Of Breast Cancer In Younger And Metastasis Of Axillary LymPh Nodes

Objective:To explore the clinic-pathaloical characteristics,biological characteristics and axillary lymph nodes metastasis routine of young patients with breast cancer and improve diagnosis and treatment. Methods: The 252 cases which were treated and confirmed breast cancer by biopsy at the tumor,s hospital affiliated xinjiang autonomic area in the period of From 2002,jan to 2006,Oct were collected.The clinic- biological characteristics,such as age range,clinical stage,toumor sizepathaloical type and C-erbB-2,ER,PR status of the cases and their correlation between the metastasis of axillary lymph nodes were analyzed retrospectively. Results: There were 8.27% (252/3048)of young patients among all breast cancer cases collected during the same period.Of the young patients ,93.65%(236/252) were invasive cancer. Axillary Lymph nodes metastasis rate were found in 63.89%(161/252)of the young patients. The positive rates of ER,PR,C-erbB-2 in young patients were 46.19%(97/210),47.61%(100/210)and 35.43% (73/206) respectively. The cases of tumor size>2㎝ had a high axillary lymph nodes metastasis rate than the group of toumor size≤2㎝ (P<0.05). the percentage of stageⅠ～Ⅱand stageⅢ～Ⅳwas 45.24%(114/252)and 54.76%(138/252) respectively. the statistic analysis indicated that,there was a correlation between the axillary Lymph nodes metastasis rate and the tumor stage, the more late the tumor stage,the more high axillary Lymph nodes metastasis rate(P=0.00);Also there was a correlation between the C-erbB-2 status and the axillary Lymph nodes metastasis rate, the more positive C-erbB-2 rate ,the more high axillary Lymph nodes metastasis rate (P<0.01);but there were no significant correlation between the positive rates of ER,PR with the axillary lymph nodes metastasis rate(P>0.05). Conclusion: 1)Breast cancer in young women had high histological grade,the parameter of strong invasion,pathalogical types were maily invasivecancer. 2)there was a correlation between the the toumor size,tumor stage and C-erbB-2 with axillary Lymph nodes metastasis of Breast cancer in young women. 3)there were no significant correlation between the status of ER,PR with the axillary lymph nodes metastasis of Breast cancer in young women.