Study On The Phlegm-Stasis Syndrome In Complex Diseases And The Prethrombotic State

Objective: To study the proportion of phlegm-stasis syndrome in complex diseases and to explore its relations to Prethrombotic State. Methods: The expression of CD41, CD62P on platelets, the level of plasma tissue plasminogen activator (t-PA), Plasminogen Activator Inhibitor-1(PAI-1),Activated partial thromboplastin time (APTT), Fibrinogen ( Fib), Prothrombin time ( PT) and Thrombin time (TT) were tested by using Flow Cytometer, ELASA method and auto coagulometer. Results: 1.The proportion of phlegm-stasis syndrome in complex disease was 76.84%, non-phlegm-stasis syndrome was 23.16%; the proportion of phlegm syndrome in phlegm-stasis syndrome was 24.66%, stasis syndrome was 19.18%, stagnation of phlegm and stasis syndrome was 56.16%. 2.â‘ Compared to control group, there was no significant difference on the expression of platelet CD41 and TT in phlegm-stasis syndrome group(phlegm syndrome, stasis syndrome, stagnation of phlegm and stasis syndrome groups )(P>0.05); however the expression of platelet CD62P was higher (P<0.01) in phlegm-stasis syndrome group(phlegm syndrome, stasis syndrome, stagnation of phlegm and stasis syndrome groups); the level of plasma t-PA was lower(P<0.05) in phlegm-stasis syndrome group (phlegm syndrome group P>0.05, stasis syndrome, stagnation of phlegm and stasis syndrome groups P<0.05); the level of plasma PAI-1 was higher(P<0.05) in phlegm-stasis syndrome group (phlegm syndrome, stasis syndrome groups P<0.05, stagnation of phlegm and stasis syndrome group P<0.01); the level of plasma Fib was higher(P<0.01) in phlegm-stasis syndrome group (phlegm syndrome, stasis syndrome, stagnation of phlegm and stasis syndrome groups P<0.01); PT, APTT was shortened(P<0.01) in phlegm-stasis syndrome group (phlegm syndrome, stasis syndrome, stagnation of phlegm and stasis syndrome groups P<0.01).â‘¡Compared to non-phlegm-stasis syndrome group, the expression of platelet CD62P was higher(P<0.01)( phlegm syndrome group P>0.05, stasis syndrome group P<0.05, stagnation of phlegm and stasis syndrome group P<0.01), and the level of plasma Fib of phlegm-stasis syndrome group were higher(P<0.01)( phlegm syndrome group P>0.05, stasis syndrome group P<0.05, stagnation of phlegm and stasis syndrome group P<0.01), although the expression of platelet CD41, the level of plasma t-PA, PAI-1, PT, TT and APTT were insignificantly different between two syndrome(P>0.05), each the items above had a certain gradient on phlegm syndrome, stasis syndrome, stagnation of phlegm and stasis syndrome and non-phlegm-stasis syndrome groups, and the changes were the most obvious in stagnation of phlegm and stasis syndrome groups. Conclusion: 1.phlegm-stasis syndrome is more common and is one of the important syndrome types of complex disease; stagnation of phlegm and stasis syndrome are more prevalent than phlegm and stasis, stagnation of phlegm and stasis are the common result of phlegm and stasis. 2. There is a different degree of prothrombotic state in phlegm-stasis syndrome of complex disease; the changes of prethrombotic state including the expression of platelet CD62P, the level of plasma t-PA, PAI-1, Fib, PT and APTT are more obvious in phlegm-stasis syndrome than that of the non-phlegm-stasis syndrome.