The Study Of The Relationship Between The Syndrome Differentiation Of TCM And The Levels Of High-sensitivity C-reactive Protein,Macrophage Migration Inhibitory Factor Expressed In Ischemic Stroke (Meridian-apoplexy)

ObjectiveTo observe the relationship between the syndrome differentiation of TCM and the levels ofhigh-sensitivity C-reactive protein,macrophage migration inhibitory factor expressed inIschemic Stroke (meridian-apoplexy) and to discuss the possible mechanism of differentTCM Syndrome-Type marker variance, for the purpose to further clarify the key ofpathogenesis and to seek the objective bases of syndrome differentiation-tying in TCM ofIschemic Stroke, so as to promote the syndrome differentiation-tying in TCM of IschemicStroke more standardization.Methods80 patients with Ischemic Stroke (meridian-apoplexy) were classified in to five groupsaccording to the measuring scale of dialectical diagnostic code about stroke: Liver-yangexcessive rising group,Wind-phlegm with congestion emphraxis meridian,Phlegm-heatwith blocked intestines,Qi differency with blood-stasis group,In deficiency and wind actgroup, and a control group containing 20 healthy subjects.We score the neurological impairment and measure infarction lesion in 24 hours. Thecontents of MIF and hs-CRP were measured by ELISA(enzyme linked imrnunob- sorbentassay).ResultsThe level of serum hs-CRP of the patients with Ischemic Stroke(merdian-apoplexy) aresignificantly higher than that of the healthy control group.(P<0.01) The orders of serumhs-CRP expression of patients in different groups from top to low are Phlegm-heat withblocked intestines group, Qi difficency with blood-stasis group, Wind-phlegm withcongestion. emphraxis meridian group, Liver-yang excessive rising group and Yin Deficiency and wind act group. Among them, the level of serum hs-CRP in Phlegm-heatwith blocked intestines group and Qi difficency with blood-stasis group expressed aresignificantly higher than those of Yin Deficiency and wind act group.2,The level of serum MIF of the patients with Ischemic Stroke (merdian -apoplexy) aresignificantly lower than that of the healthy control group,(P<0.01). The level of serum MIFin Qi difficency with blood-stasis group is significantly lower than that in Yin Deficiencyand wind act group. The orders of serum MIF level of patients in different groups fromlow to top are Qi difficency with blood-stasis group, Phlegm-heat with blocked intestinesgroup, Wind-phlegm with congestion emphraxis meridian group and Liver-yang excessiverising group, and the comparison between groups has no statistical meaning.3,The NIHSS scores of Phlegm-heat with blocked intestines group and Qi difficency withblood-stasis group are significantly higher than that of Yin Deficiency and wind act group(P<0.01). The orders of NIHSS score of patients in different groups from top to low arePhlegm-heat with blocked intestines group, Qi difficency with blood-stasis group,Liver-yang excessive rising group and Wind-phlegm with congestion emphraxis meridiangroup, and the comparison between groups has no statistical meaning.4,The serum hs-CRP expression of the Ischemic Stroke patients with mild, moderate andsevere had an increasing tendency. In the comparison between every two groups,the levelsof serum hs-CRP expression in moderate patients are significantly higher than that ofmild patients, (P<0.01).The comparison between the severe patients and other two groupsare of no statistical significance because of its amount.5,The serum MIF expression of the Ischemic Stroke patients with severe, moderate andmild had an decreasing tendency. In the comparison between every two groups,the levels ofserum MIF expression in moderate patients are significantly lower than that of mildpatients. (P<0.01) The comparison between the severe patients and other two groups are ofno statistical significance because of its amount.Conclusions1,The contents of MIF and hs-CRP in serum can be rgarded as the essences inforecasting neurological impairment of people with IS.2,The levels of MIF and hs-CRP imply the possible mechanism of different TCMsyndrome-Type marker's variance. There is a certain relationship between MIF,hs-CRPand syndrome differentiation-Tying in TCM of Ischemic Stroke.3,Patients of Phlegm-heat with blocked intestines group and Qi difficency withblood-stasis group expressed are significantly higher than other type of Ischemic Stroke.Their infarction lesion are bigger,and they are in a more serious condition. Phlegm and Stasis may be the key of pathogenesis in Ischemic Stroke.