Association Of Monitoring Mycophenolic Acid Trough Level In Renal Transplantation Recipients With Acute Rejection

Objective and MethodsTo observe and analyze association of monitoring mycophcnolic acid(MPA)trough level in renal transplantation recipients with acute rejection.194 renal transplantation recipients were involved in this research,who received triple combined immunosuppressive regimen:mycophenolate mofetil(MMF)combined with calcineurin inhibitor(cyclosporine or tacrolimus)and steroid.Monitoring MPA trough level of these patients after renal transplantation,analyze the association with early acute rejection(in one month).ResultThere were 15 renal transplantation recipients suffered with acute rejection in one month post-transplantation brought into this research,compared with the recipients without acute rejection,there was no difference between their MPA level in the first, second,third and forth week after transplantation(5.85±3.13 vs.3.60±2.48mg/L,p =0.05;1.85±0.91 vs.2.46±1.99mg/L,p=0.462;2.37±0.24 vs.2.27±1.70mg/L, p=0.934;1.95±0.10 vs.2.25±1.62mg/L,p=0.794).The association of MPA levels and other clinical variables with acute rejection was analyzed by population averaged logistic regression,but there was no association between them.According to the different calcineurin inhibitors,we divided these recipients into two groups: cyclosporine group and tacrolimus group,and we find MPA levels between these two groups are different,the cyclosporine group has lower MPA level(p＜0.0001).ConclusionWhether or not suffered with acute rejection within the first month post-transplantation had no association with MPA trough level,the necessity of monitoring mycophenolic acid trough level to prevent acute rejection was not assuring.