The Comparison Of LDL Changes With CAD Prognostic Index In CHD

Objective to evaluate the LDL level after intensive statins treatment and its relationship with CAD prognostic index among the patients that diagnosed CAD and have undergone CAG for at least twice, as well as the safety and effectivity of intensive statins treatment and its impact on fast glucose. Methods patients who were diagnosed CAD in Sir Run Run Shaw Hospital Cardiology department between 2005 and 2008 with at least twice CAG procedure within 9months-18months are picked out randomly for analysis of their LDL,CK,ALT dynamic level and the statins, antiplatelet drags they took. The coronary artery pathological changes are estimated with CAD prognostic index. Sex, body weight, diabetes, hypertension and cigarette histories are also recorded for statistic analysis.(patients with acute myocardial infarction, active liver disease, muscle disease are excluded.) Results 74.4% of the patients selected achieved the ideal LDL level. Compared with the CAD patients who had similar or even decreased CAD prognostic indexes, patients whose CAD prognostic indexes increased demonstrated a smaller amplitude of LDL level decrease, and these patients had an apparent increase on ALT and CK level during two periods. Patients with LDL level decrease proportion < 30% is more likely to get an increased CAD prognostic indexes. But this phenomenon couldn't be observed among patients with LDL level decrease proportion >50%. Conclusion LDL level is an important and effective index for the prognosis of CAD, according to this research, there is strong correlativity between the decrease of LDL level and progress of CAD estimated by CAD prognostic index. For most post-PCI patients, statins treatments at a normal dose can help get the ideal LDL level. The more amplitude of LDL level decrease patients get, the less progress their disease will make. This research also hints that statins may have an effect on ALT and CK level.