Clinical And Epidemic Analysis Of 297 Mycoplasma Pneumoniae Pneumonia In Children

Purpose : Acute repiratory infection is one of the most common diseases among children world-widely,pneumonia is the first important reason that resules in children's deaths in developing countries and the most serious threatens to children's health,it has been listed as one of the four diseases protected and cured by the Medical department.Mycoplasma Pneumoniae(MP) is one of the important pathogens that cause infectious pneumonia and other respiratory infections in children .MP infection can happen in the entire year ,with higher incidence rate especially in winter,spring and autumn.The most common clinical manifestations of Mycoplasma Pneumoniae infection is respiratory symptoms ,such as fever,cough,wheeze,with many common complications ,such as myocarditis,skin lesion and degestive system,urinary system,central nervous system that being introubled.Monirity of thr extrapulmonary complications are too serious and have a longer curse ,they will prognose worse if without in-time treatment even kill lives.One recent report showed that etrapulmonary complications happened as the initial clinical symptom had been increased gradually and were misdiagnosed easily.Aims of this reserch are to explore he clinical features,manifestations of etrapulmonary organs invovled and prognosis of Mycoplasma Pneumoniae pneumonia in Children;to study the epidemic regularty of Mycoplasma Pneumoniae pneumonia in Children,thereby to provide feasible evidence for promoting the level of diagnosis and treatment.Methods:We retrospectively investigated the clinical and accessory examinational materials of 1521 chilidren diagnosead as pneumonias (including 297 MP pneumonia) admited to The Second Hospital affiliated to Da Lian Medical University from 2002 to 2007.Collecting all the diseased children'blood from the twig of vein,using dot immunogold filtration assay (DIGFA) to test the specific antigen of MP(IgM and IgG)and to do CAT,blood routine examination,biochemical examination,myocardial enzymes,renal function test and to do urinary and stool routine test.and chest X-rays.To do the ECG,EEG,chest CT and supersonic inspection of Type B selectively.Recording all the above inspection results,general run of things (age,sex,time to the hospital address)and clinical materials of every patients,then to analyse these materials comprehensively.The data was processed by statistical software SPSS 14.0 and with significance when probablity value was less than 0.05.Results:1.The incidence of Mp pneumonia in children in our hospital during 2002~2007 was 12.44%,18.50%,19.12 %,24.92%,32.42%,10.66% respectively;the average incidence was19.53% ; Generally speaking,the differences between yearly incidences have statistical significance with probablity value less than 0.05,the incidence of year 2006 came out top and was the epidemic year;2.The incidence rates of different seasons were 15.03% in spring,11.32% in summer,27.24% in autumn,22.22% in winter,the incidence between spring and summer has no stasistical significance,and the incidence between winter,autumn and summer has stasistical significance,the epidemic seasons were winter and autumn;3.The group we studied had 149 female cases and 148 male cases.The incidence of different genders were 21.1% in male and 28.57% in female and the diffence between them had statistical significance(p﹤0.05).4.The group we studied included 70 nurseling cases ,made up 23.57% and 227 cases with ages above 3,made up 76.43%.But the incidence of MP pneumonia in children under age of 3 had a tendency to increase with time;5.There were 138 children we studied had happened extrapulmonary complications which made up 46.5% of the whole objects,among which invoveled 54 urinary systemal cases,38 vasocardiary systemal cases and 23 other pathological changes, these complications cured naturally when the ihfection was controlled;6.Almost all these cases were given Erythrocin sequential treatment,within which 218 cases were combined with Ceftriaxone.Two most seves cases responded invalidatedly to Erythrocin combined with Ceftriaxone,and were changed to be treated with Amikacin,Immunoglobulin and glucocorticoid,then their symptoms improved rapidly.Average time of hospitalization of the cases we studied were 15.8±1.06 (days),all cases were cured when discharged.Conclusions:1.The year 2006 was the epidemic year of Mp pneumonia in Children in our district;2.The high-incidence seasons of Mp pneumonia in Children were winter,autumn and spring in our district;3 The difference of incidence of Mp pneumonia in Children in different genders has statistical significance;4.Mp pneumonia in Children aging above 3 years has a higher incidence than children under 3 years, but the incidence of Mp pneumonia in Children under 3 years has been increased yearly ; 5 Extrapulmonary complications of MP pneumonia in Children in this group have a high incidence but good prognosis with no death and sequela;6 Erythrocin sequential treatment combined with Ceftriaxone and added with immunized medicine when nessary has a good healing effect.