The Study Of VEGF,bFGF And Anti-angiogenesis Therapy In Diagnosis And Therapy Of Lung Cancer

Objective:To analysis the value of VEGF and bFGF in lung cancer diagnosis and treatment and their role in angiogenesis inhibition, the peripheral Plasma VEGF and bFGF level in patients with lung cancer were determined, and their changing before and after drug treatment were also observed. We hope our results can provide some experiment foundation for anti- angiogenesis treatment and individualized treatment against lung cancer.Methods: Totally 160 lung cancer Patients and 50 healthy examinees were selected for this research. All the patients and healthy examinees were divided into 3 groups according to the experiment design. Fasting vein blood samples were drained and the serum VEGF and bFGF level were then determined by ELISA method. All the results were analyzed by SPSS static s software.Results:1.For the lung cancer patients, their peripheral blood VEFG level is higher than the healthy control group(p<0.01), and the bFGF level was also higher than the healthy control.2. No significant difference detected in lung cancer patients of different age, sex, smoking or not, and different histological type(p>0.05).3. The peripheral serum VEGF and bFGF level in lung cancer patients are correlated with their clinical stages and their condition of lymph nodes metastasis(p<0.05), especially inâ…£stage patients.4. Comparison of before and after chemotherapy: for small cell lung cancer(SCLC),serum VEGF and bFGF reduced significantly in complete remission(CR) and partial remission(PR) group(p<0.05), while for no change(NC) and progressing(PD) group, no significantly changing of serum VEGF and bFGF change detected(p>0.05); for squamate cell lung cancer(SQLC), serum VEGF and bFGF also reduced significantly in CR and PR group (p<0.05), while for NC and PD group, no significantly changing of serum VEGF and bFGF change detected(p>0.05); for lung adenocarcinoma; serum VEGF reduced markedly in CR group, but no in PR,NC and PD group, serum BFGF reduced in CR and PR group, but no in NC and PD group. For 100 lung cancer patients of different histological, serum VEGF and bFGF reduced after chemotherapy but not in NC and PD group.5. Chemotherapy plus anti-angiogenesis medicine thalidomide have better curative effects than chemotherapy only, but did not show enough statistic significance (p>0.05), and the reduction of serum VEGF and bFGF did not show statistic significance between this two groups, either.6. In lung cancer patients, there are some correlation between their serum VEGF and bFGF level. Conclusion: 1. serum VEGF and bFGF are closely related with the diagnosis of lung cancer, the clinical stages, the conditions of lymph nodes metastasis and the curative effects of the lung cancer.2. Our results indicated that no difference existed in serum VEGF and bFGF level among lung cancers of different pathological type, this may told us the detection of serum VEGF and bFGF are no use in distinguishing the pathological types of lung cancer.3. The anti-angiogenesis medicine Thalidomide has some benefits for lung cancer therapy, but not to much. 4. The expression of serum VEGF and bFGF are correlated in lung cancer Patients, so the combined detection of these two cellular factors can increase the detective efficiency of lung cancer.