Curative Effect Of Synchronous Radiochemotherapy In Medium-term And Advanced Cervical Carcinoma

Objective:To investigate the curative effect of synchronous radio-chemotherapy in medium-term and advanced cervical carcinoma.Methods:To select 168 cases of medium-term and advanced cervical carcinoma.The treatment group(Grout A) included 84 pathologically verefied cases of stageⅡ～Ⅳcervical carcinoma. Each patient was given DDP with hydration at the dose of 40mg/m² intravenously.The treatment cycle was performed once every week for 3～4 circles.Radiotherapy was given at the same time. 6MV-x linear accecelerator was used for external radiation with a total dose of 50Gy,¹⁹²Ir afterloading unit was used for brachytherapy at the dose of 7Gy per week at point A with a total dose of 42～47Gy.The control group(Group B)included 84 cases of cervical carcinoma at the same stage in the corresponding period who received radiotherapy only.Short-term effect, 2-year survival rate and complications were observed.Results:Effective rate was 92.85%(78/84) in Group A and 79.76%(67/84) in Group B respectively 3 months after radiotherapy,showing a signi-ficant difference(x²=6.10,p＜0.05). 2-year survival rate was higher in Group A(80.95%) than in Group B(59.52%)(x²=9.4,p＜0.05).Local recurrent and distant matastasis were lower in Group A than Group B.In group A,there were tolerable bone marrow inhibition and reaction of digistive tract.Conclusions:Synchronous radiotherapy and chemotherapy can remarkably improve the short-term effect and the survival rate of 2 year of medium-term and advanced cervical carcinoma.The application of DDP is effective and safe,and its side effect can be accepted by patients,but the long-term effect needs further observation.