The Expression And The Relation Of TSLC1 And E-cadherin In Cervical Squamous Carcinoma By Tissue Micro Array

Objective:To detect the expression of TSLC1 and E-cadherin in cervical cancer by tissue micro array and to evaluate their clinical significance and correlation between the two genes.Methods:59 specimens of tissues,including squamous carcinoma of the cervix,CINs and normal tissues underwent micro array examination and immunohistochenmistry to detect the expression of TSLC1 and E-cadherin.The intensity of TSLC1 and E-cadherin protein were investigated by analyzing with imaging technique.Results:The result showed that the expression of strong positive cell in normal cervical tissue and CINⅠwere significant higher than those of CINⅡ,CINⅢand squamous carcinoma of the cervix(P＜0.05).There was no association between TSLC1 expression and histological type(P＞0.05).But the expression of TSLC1 was significantly correlated with lymphatic metastasis(t =4.558,P =0.000).Inactivation of E-cadherin gene expression in cervical cancer was significantly related to do with lymphatic metastasis and histological type(P＜0.05).The expression of TSLC1 and E-cadherin in cervical tissue were positive correlation(r=0.678,P=0.000).Conclusion:Tissue microarray technique is effective method to detect multiple gene protein expression.Inactivation of TSLC1 and E-cadherin gene expression is an important factor in the uterine cervical carcinogenesis.