Study On The Correlations Of Plasma Adrenomedullin And Transforming Growth-factor-β1 Levels In The Patients With Diabetinephropathy

Objective To study the blood level of adrenomedullin(AM)and transforming growthactor-β1(TGF-β1)in patients of different stage of type 2 diabetic nephropathy(DN),and primarily explore the changes and relationship between AM and TGF-β1 in pathogenesis of DN.Methods We select 15 cases of controls and 80 cases of T₂DM patients; patients were divided into 4 groups according to UAER;T₂DM without DN (groupA),T₂DM with DN in initial stage(groupB)and T₂DM with DN in clinical stage(groupC).T₂DM with DN in end stage renal disease(groupD).Investigate the levels of plasma adrenomedullin,serum TGF-β1,urinaryα1-MGβ2-MG,and;Analyze the correlation and function of plasma adrenomedullin and TGF-β1 in DN.Biochemical data were measured simultaneously.Results The serum levels of AM and TGF-β1 were significantly higher in T₂DM and DN than in controls(P＜0.01),higher with the development of illness in DN patients than those of type 2 diabetic patients without DN(P＜0.01/P＜0.05),and elevation accompany by UAER and creatinine(P＜0.01).The level of AM positively correlated with the level of TGF-β1 in patients with diabetic nephropathy (r=0.326,P＜0.01).The level of AM positively correlated with the urine levels ofα1-MG andβ2-MG in patients with DN(P＜0.01).Conclusion AM and TGF-β1 were closely associated with the pathogenesis and progression of diabeticnephropathy.TGF-β1 was one of the important factors reflecting the injury of diabetic kidney and the elevation of AM in circulation may be a compensatory and protective reaction in these patients.AM may be a new index which can reflect the factions of renal tubule fatction.