The Reaserch For Risk Factors In Patients With Inflammatory Bowel Disease

[Background and objective]Inlammatory bowel disease is the most common and frequently occurring disease in digestive system. Ulcerative colitis(UC)and Crohn's disease(CD) were included. The morbility of IBD in China has upgraded along with the alteration of life style and the elevation of recognition and diagnosis. But also, the quality of life in patients with IBD has been effected. We should pay close attention to it. There were already many investigations about the etiology of IBD. The etiology of IBD is considered to be caused by immunifaction, heredity, environmental factor, diet, microbial factor, and so on. Our objective is to research the risk factors of patients with IBD.[Methods]Eighty patients who were diagnosed by endoscopy and (or) pathology from 2005 to 2007 in Qilu Hospital of Shan Dong University were chose as case group. We also chose eighty person who were the mates or relatives of the case group as control group. All of them live together. We chart a questionnaire concerning age of onset, gender, exposure to environmental and diet factors before the diagnosis of IBD to observe whether there is significant difference between the two groups, and help us to estimate the factors which may effect IBD. We also collect factors in patients with relapse, in order to estimate the factors which may concern with the relapse.[Results]All of the eighty patients with IBD , 70 patients were UC,10 patients were CD. The number of male patients is 47, while the number of female is 33.The ratio is 1.42:1.The predilection age of onset is 20～40y. In patients with UC, the difference between the two groups is significant(P<0.05). Using Logistic analysis, the result is: no-smoking, mental stress and capsicum are concerning with the IBD, while mental stress, capsicum and graduation of the IBD are concerning with the relapse.Among all the patients, 2 patients also with GDM, 3 patients also with cerebrovascular disease, 4 patients also with rheumatoid arthritis, 3 patients also with disease of respiratory system, 2 patients also with chronic viral hepatitis B.[Conclusions]Non-smoking, capsicum and mental stress may be the risk factors. Not only the therapy, but also the habits as well as psychology are should be pay attention to the patients with IBD. We should also pay attention to health education in population, in order to prevent IBD.