Study On The Therapeutic Effects Of Hemoperfusion For Acute Severe Dichlorvus Poisoning

Purpose: To assess the efficacy of hemoperfusion (HP) treatment for beagles with acute severe dichlorvus poisoning by statistic analysis.Methord: Ten beagles with intravenous administration of dichlorvus were divided randomly into control group (without hemoperfusion treatment)and HP group (with hemoperfusion treatment). Serum concentration of dichlorvus and the activity of butyrylcholinesterase were dynamicly measure, the clinical effects were judged, and the amount of toxicant in the main tissue was tested. Toxicodynamics was analyzed by DAS 2.1.1, and the data were statistically analyzed by two-tailed t-test.Results: First, the distribution of dichlorvus fits two-compartment model, the main parameters of toxicodynamics were V(d17.803±10.345)L/Kg,t1/2(6.260±3.078)h and Cl(1.955±0.757)L/h/Kg. Second, comparison of toxicodynamics parameters of two groups was different during two-hour HP treatment, but that was not different during 48 hours. Activated charcoal which could efficiently absorbe the dichlorvus in blood only remove a very little( < 2‰) total body burden of dichlorvus.The activity of butyrylcholinesterase in two groups was not different. During the observation, the cumulative dosages of atropine required, at the beginging of breath failure,the endurance of mechanical ventilation and morality in two groups were not different.Conclusion: One hemoperfusion of activated charcoal may not an ideal therapeutic method for acute severe dichlorvus poisoning.