Radiation Damage Of The Common Carotid Artery With Implantation Of I-125 Brachytherapy Seeds In Rabbits

[Objective]To apply factorial design in investigating the radiation damage of the common carotid artery of rabbit with ¹²⁵I brachytherapy seeds implantation,and evaluate the security of the seeds implantation brachytherapy.[Methods]16 healthy male New Zealand rabbits weighing 2.5～3.0kg were divided into 8 pairs by heterogeneous paired rules.Two groups(14d, 30d)were made further randomly,each group had 4 pairs.Two rabbits in the each pair were respectively distributed into two groups:test group (0.5 mCi×3)and control group(non-radioactive seeds×3).On the 14^th day and the 30^thday after operation,the carotid artery of animals of the corresponding group underwent gross,histopathologic examination,and transmission electron microscopy.All the statistical analysis was performed by STATA 7.0 software.[Results]Perforation and thrombogenesis were not observed in both test group and control group on 14^thday and 30^thday.Statistical analysis of the inflammation score did not differ significantly between the 2 groups (P＞0.05).Injuries of radiosensitive cellular organelle were observed by transmission electron microscopy in test group,but did not differ significantly between the 14^thday group and the 30^thday group.[Conclusion]0.5mCi ¹²⁵I brachytherapy seeds implantation(interval 10mm) implantation is a safe clinical management with little radiation damage.