Laryngoscopy And Immunologic Index Detection In The Patients With Laryngeal Cough

ObjectiveTo investigate the immunologic index and laryngeal sign and to determine if significant relation existed between laryngeal cough and allergic inflammation.MethodsThirty-six healthy volunteers and sixty-six patients clinically diagnosed as laryngeal cough entered the study. The patients were divided into two groups, one with allergic rhinitis and the other without allergic rhinitis. The blood serum eosinophilic granulocyte and inhalant allergen skin test were detected. The serum specific IgE was measured by Sweden Pharmacia CAP system. The larynx was examined by electriclaryngoscopy.ResultsThere was no statistical difference of inhalant allergen skin test, eosinophilic granulocyte and specific IgE between the laryngeal cough without allergic rhinitis and control group. But the difference was statistically significant between the laryngeal cough with allergic rhinitis and control group. The most frequent laryngeal findings, which were seen in 71.4% cases of the laryngeal cough with allergic rhinitis, were congestion, edema or pale mucosa of the laryngeal wall in aritenoid district. In laryngeal cough without allergic rhinitis group, 26.3 % cases had the abnormal laryngeal findings. Relatively, there was only 11.1% in control group.ConclusionsThe laryngeal cough with allergic rhinitis may be relevant with allergic inflammation. There was no significant relation between laryngeal cough without allergic rhinitis and allergic inflammation. In this condition, the laryngeal cough may be relevant with neurogenic inflammation or other factors, but its pathogenesy needs further research.