Study Of Exercise Intervention On Quality Of Life And Therapeutic Effects In Newly Diagnosed Type 2 Diabetic Patients Or The Patients Of Impaired Glucose Tolerance

Objective: To evaluate the effects on quality of life(QOL) in newly diagnosed Type 2 diabetic patients or the patients of impaired glucose tolerance (IGT) before and after intervention; To explore the effects of exercise on QOL , clinical effects and the direct cost-effect of lowering blood sugar in newly diagnosed Type 2 diabetic patients or the patients of IGT; To explore the clinical factors which affected QOL in newly diagnosed Type 2 diabetic patients or the patients of IGT. To provide theoretical base and practical instruction on exercise intervention for diabetic patients in hospital and community .Methods: According to stratified sampling method, 162 patients , who were newly diagnosed Type 2 diabetes mellitus and IGT from 6 hospitals in Hunan province, were divided into the experimental group and the control group randomly. All the patients in the control group were given a standard diet, phisical exercise and health education. Those in the experimental group strengthened physical exercise twice a day extraordinarily. The patients were evaluated by using DMQLS which were made by Wang le-shan and the self appraisal-sheet of health-state which were made by myself, the clinical signs including body mass index, glycosylated hemoglobin, fasting blood glucose and postmeal blood glucose were tested before and after intervention too. We compared the scores of QOL, the state of clinical signs, the targeted rate of clinical signs and the health improvement rate before and after intervention , analyzed the clinical factors which affected QOL. Statistical analysis included descriptive statistical analysis, t test, repetitive measure analysis of variance , chi square test, multiple linear stepwise regressions.Result: 1. There were significant differences among groups of different intervention and different test time on all dimension of QOL except disease; furthermore, significant interaction effect existed between intervention and time (all P=0.000) .2.Significant difference existed on clinical signs among groups of different intervention (all P<0.05); Significant difference existed on BMI,HBA₁C among groups of different test time ; Furthermore, there was significant interaction effect between intervention and time (all P=0.000). The variation trend on FBG and PBG is different from the two interventions and those test time3. After intervention for half year, statistical significance was found between the control group and the experimental group on the targeted rates of clinical signs and the health improvement rates4. After intervention for six months, compared to the control group, the direct cost-effect ratio of lowering blood sugar in the experimental group were higher.5. According to the multiple linear stepwise regressions, the difference of the total scores on the quality of life before and after intervention was related to the difference of BMI, FBG, FLbA₁C and PBG.Conclusion: 1. The Physical exercise contributes to improve the quality of life of newly-diagnosed type 2 diabetic patients and the patients of IGT.2. The physical exercise helps to elevate the clinical effects and reduce the direct costs of lowering blood sugar of newly-diagnosed type 2 diabetic patients and the patients of IGT.3. The difference of the total scores in the quality of life before and after intervention is related to the difference of BMI, FBG, PBG and HbA₁C.