| Objective:To investigate the association of the 5-HT2Creceptor gene-759C/T and-697C/G polymorphism with therapeutic response to antipsychotics in first-episode schizophrenic patients,attempt to broaden the field of medicine research and provide beneficial evidence for the exploration of novel antipsychotics,individualized therapy and etiopathogenesis of schizophrenia.Methods:179 first-episode schizophrenic patients were investigated with the self-compiled inventories and had been treated by risperidone and clozapine for 8 weeks.The severity of symptoms and the therapeutic responses to risperidone and clozapine were evaluaded by the positive and negative symptom scale(PANSS).The patients were divided into two groups according to the reductive rate of score of PANSS≥50%and＜50%respectively.The genotypes and allele frequencies of 5-HT2C receptor genes were assayed by polymerase chain reaction(PCR) amplification and Restriction Fragment Length Polymorphism(RFLP) technique.The data analysis used with x2 test and t test.Results:1.The frequencies of C/C genotype of the 5-HT2Creceptor gene -759C/T polymorphism was significant difference with C/T genotype and T/T genotype between response and non-response to risperidone group in total clinical efficacy(female gender).There were significant difference of C/C,T/T,T/C genotypes frequencies between response and non-response to negative symptom with risperidone therapy.And no significant difference of T,C allele frequencies was found between the two groups.2.The C/C genotype frequency of the 5-HT2Creceptor gene -697G/C polymorphism was not significantly different from C/G genotype and G/G genotype between response and non-response to risperidone group in total clinical efficacy.There was significant difference of G,C allele frequencies between the two groups(female gender).No significant difference of C/C,C/G,G/G genotypes and G,C allele frequencies was found between response and non-response to negative symptom with risperidone therapy.3.No significant difference of C/C,C/T,T/Tgenotypes and T,C allele frequencies of the 5-HT2Creceptor gene -759C/T polymorphism was found between response to clozapine group and non-response to clozapine group of total clinical efficacy.The frequencies of C/C genotype of the 5-HT2Creceptor gene -759C/T polymorphism was significant difference with C/T genotype and T/T genotype between negative symptom response to clozapine group and negative symptom non-response to clozapine group(female gender).No significant difference of T,C allele frequencies was found between the two groups.4.No significant difference of C/C,C/G,G/Ggenotypes and G,C allele frequencies of the 5-HT2Creceptor gene -697G/C polymorphism was found between response to clozapine group and non-response to clozapine group of total clinical efficacy.There was significant difference of G,C allele frequencies between negative symptom response to clozapine group and negative symptom non-response to clozapine group.No significant difference of C/C,G/G genotypes frequencies was found between the two groups.5.Genotypes and allele frequencies of 5-HT2Creceptor gene -759C/T and -697G/C polymorphism were not significantly different between response and non-response in positive symptom group.6.We did not find significant difference between response group and non-response group in Gender and family history.Conclusions:1.5-HT2Creceptor gene -759C/T and -697G/C polymorphism may associate with clinical response to antipsychotics on first-episode schizophrenia.C/C genotype and C allele is likely to be a predictive factor to the improvement of total therapeutic effect and negative symptom with treatment of antipsychotics2.Gender and family history may be not associated with therapeutic effect to antipsychotics... |
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