| ObjectiveThis case control study is designed to analyze the effect of cardiovascular risk factors, blood biochemistry parameters, echocardiographic parameters, stent parameters, in the prognosis of coronary heart disease during long-term following-up in patients admitted to Tianjin Chest Hospital and received PCI treatment during 2006. and further analysis can be laid to study cardio-incidence after PCI treatment.Target and Methods1. Study patients: 5403 consequentive in-patients were accepted CAG were selected, including3162 patients with definite diagnosis of CHD, and 1495 patients were received PCI treatment during 2006. After review of inclusion and exclusion criteria, 1367 patients experienced PCI inhospital, and satisfying both criteria were ultimately enrolled in the present study.2. Study content: The date of demography, cardiovascular risk factors (smoke, hypertension, diabetes, family history, blood biochemistry, inhospital echocardiographic measurements ( LVEF,LVEDD ), diameter and length of the stents, the pharmacological treatment were collected and correlated with the cardiovascular events occurred during following-up period.3. Follow-up methods: The following-up methods used in this study included: telephone consultation and clinic consultation. And the main method was the former. The items of follow-up included death, recurrence of cardiovascular events, after hospital discharge drug treatment, etc.4. The definition of end-points: The end-points used in this study include all cause deaths, cardiogenic deaths, non-fatal MI, congestive heart disease, unstable angina, revascularization (PCI or CABG)5. Statistic method: Analyze the data used the statistic software SPSS 13.0. Chi square test or Fishers exact test were used to compare numeration data between groups. Scale data were expressed with mean±SD, T test was used to compare scale data between two groups. Logistic analysis was conducted to detect risk factor's impact on the prognosis of cardiovascular events. P < 0.05 was considered to be statistic significance.Results1. Demography data: The mean age of all 1367 selected CHD patients is 60.24±10.32 years old, the mean age of 956 male patients is 58.57±10.70; the mean age of 411 female patients is 64.10±8.16. There are 208 patients recurrence of cardiovascular events totally. 744 patients' age is above 60.2. Risk factors: Most patients in the follow-up study had CHD risk factors. The risk factor in this cohort patients included smoking (58.89%, 805/1367), hypertension (58.81%, 804/1367), diabetes (20.12%, 275/1367) and lipid disorders (22.68%, 310/1367). The distributions of various risk factors including smoke, hypertension, diabetes were significantly different between the group with and without cardiovascular events (P<0.05).3. Folio wing-up: The patients were followed for 10-21 months, with the mean following-up period of 13.38±2.13 months, the rate of following-up population was 91.44%, 208 patients happened to cardiovascular events and takes a rate of 15.22%; 85.95% of the patients were insisting on taking aspirin. There are only 312 patients adhered to statin treatment less than 3 months, and 758 patients during 3 to 9 months, only 297 patients were receipted last more than 9 months.4. Blood biochemical indicators: There are significant difference between groups with and without events during follow-up in terms of following blood biochemical parameters inhospital: TC, TG, LDL-C, GLU, however no significant difference in HDL-C.5. It's significant correlated between the type of CHD, the number of cardiovascular involved in, the type of stents planted in and the end-point events.ConcIusionThe patients accepted PTCA and PCI showed well prognosis during the following-up. Traditional risk factors including smoking, DM, hyper blood lipids should be under control to limit the incidence rate of cardio-vascular events. |
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