P-gp, C-erbB-2 With Human Tumors

The drug resistance leads to the chemotherapy failure. The mechanism of the drug resistance is very complicated,so far, the most important mechanism of the drug resistance is the over expressing of Mdr1,it's production is a glycoprotein (P-gp).Protein c-erbB-2 (neu or her-2) belongs toâ… type growth factor receptors as epidermal growth factor receptor. Protein tyrosine kinase (PTK) coded by HER-2/neu made reparation DNA of G2 stage prolonged and reinfored repair enzymatic active of DNA, and then drug fast of tumour cell appeared.This article reviews the discovery , structure, function and mechanisms of P-gp and c-erbB-2 .The expressions of P-gp and c-erbB-2 in multisysterm tumors and the corelation between the expressions of P-gp and c-erbB-2 were specified.