Effects Of Antiepileptic Drugs On Cognition

Problems with cognition are common in patients with epilepsy.Multiple factors contribute to the risk of cognitive impairment.Antiepileptic drugs is the dominant therapy at present,and also impairs the cognitive function to some extent.A series of double-blind,randomized, cross-over, healthy volunteer studies have been conducted to avoid the confounding effects on cognition such as those produced by changes in seizure frequency.According to the past studies,all of the AEDs produce cognitive effects compared to the non-drug conditions,and the new AEDs have fewer and less effects on cognition than the older AEDs.Studies have also demonstrated that exposure to AEDs in utero may affect cognitive development.Although the cognitive effects of AEDs are generally modest,these effects can have clinical impact,and worthy much of our attention.