Comparison Of Clinical Outcome Between Plasma Exchange And Hemoperfusion In Treating Chronic Hepatitis Patients With Hyperbilirubinemia

Objective: To observe and compare the efficacy and safety of plasma exchange and hemoperfusion in treating patients with hyperbilirubinemia.Methods: This is a retrospective study,85 patients with hyperbilirubinemia were treated with plasma exchange and 68 patients with hyperbilirubinemia were treated with hemoperfusion. The clinical symptom, live function tests,bilirubin and prothrombin time activity, which were compared before and after, and between the two treatments, observe adverse effect in the same time.Results: After treatments, bilirubin decreases significantly, prothrombin time activity and albumin increase siginificantly after plasm exchange(541.68±186.94vs337.65±130.52,40.50±19.32vs55.29±19.45,30.12±4.24vs31.57±3.17);after hemoperfusion, bilirubin decreases, prothrombin time activity increases and albumin decreases but not significantly(482.69±189.36vs 473.58±183.57,41.63±19.85vs43.03±20.85,30.86±4.31vs30.26±3.48). Compared with hemoperfusion, bilirubin, prothrombin time activity and albumin in plasma exchange have more significance (204.03±102.04 vs9.11±87.46, -14.79±16.20vs-1.40±12.78, -1.45±2.83vs0.60±3.58, P<0.05). Both affect blood routine test. Potassium and urea nitrogen increase but within normal range.Conclusions: Plasma exchange can effectively improve liver function for patients of chronic hepatitis with hyperbilirubinemia, hemoperfusion has poorer effect.