| Objective: To study the effects of Yiwei San on gastric emptying and gastrin(GAS) in serum of mice with functional dyspepsia(FD) and investigate its mechanism.Methods: 100 KM male mice were randomly allocated to blank control group, model group, domperidone treatment group and Yiwei San treatment group, 25 of one group. Except for the mice from the blank control group, all other mice were made model by irregular food intake plus L-arginine(L-Arg) for 15 days. When the models were finished successfully, nothing but water was offered to the mice for 24 hours, then 10 mice of each group were chosen randomly and each of the mice was irrigated with semi-solid material of 0.5 gram. After 15 minutes' standing, all the chosen animals were executed, cut the belly open, took out of the stomach, calculated the residue rate of material in stomach and observed the histological change of gastric mucosa with light microscope. The other mice of each group were given corresponding intervention measures while the general condition of the mice was recorded, such as the weight. When the treatment was finished, all the mice without feeding anything but water in 24 hours were irrigated with the semi-solid material of 0.5 gram. After 15 minutes' standing, all the experimental animals were executed. We got serum or stomach specimen, and calculated the residue rate of material in stomach. Gastrin in the blood was detected by the method of radioimmunoassay.Results: Compared with that in the blank control group, the residue rate of material in stomach in the model group was distinctly statistical difference (P<0.05).The general condition and the histological change of gastric mucosa showed: all the mice had not organic diseases. The concentration of gastrin in serum in the model group was lower than that in the blank control group (P<0.05). Gastrin increased in the Yiwei San treatment group, significantly different from that in the model group (P<0.05). There was no significant difference between the domperidone treatment group and the Yiwei San treatment group (P>0.05). The residue rate of material in stomach in the Yiwei San treatment group obviously decreased compared with that in the model group (P<0.05). There was also no significant difference between the Yiwei San treatment group and the domperidone treatment group (P>0.05).Conclusion: The results have prompted that Yiwei San can accelerate gastric emptying of functional dyspepsia mice model. The results suggest that Yiwei San improved gastrin level in serum of functional dyspepsia mice model. The mechanism of treatment FD might be that Yiwei San has the effects of promoting the release of gastrin in serum and gastric emptying. |
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