Correlation Between The Levels Of Glycosylated Hemoglobin A1c, Serum Lipid And C-Reactive Protein And The Extent Of Coronary Lesions In Nondiabetic Patients With Coronary Heart Disease

Objective:To explore the relationship between the levels of glycosylated hemoglobin Alc(HbAlc),serum lipid and C-reactive protein(CRP)and the extent of coronary lesions in nondiabetic patients with coronary heart disease(CHD).Method'The plasma HbAlc concentration,serum lipid concentration and CRP concentration were tested in 135 patients diagnosed as CHD without diabetics by coronary angiography,and were compared with those of the normal control group(n=40).nsini′s coronary angiography score was calculated to show the extent of coronary atherosclerosis.The relationship between HbAlc level,serum lipid level and CRP level and coronary atherosclerosis was evaluated.Results:The mean levels of plasma HbA1c,serum lipid and CRP in CHD patients were higher than those in the control(P＜0.05).Compared with AMI group and UAP group,the levels of HbAlc were elevated in SAP group;compared with SAP group,the levels of CRP were elevated in AMI group and UAP group;the comparison between AMI group and UAP group shows no significant difference of CRP.The r between CHOL,LDL,TG/HDL and CRP with numbers of stenosed coronary artery were 0.62,0.67,0.73 and 0.71.The r between HbAlc,CHOL and LDL/HDL with coronary angiography score were 0.76,0.51 and 0.81. Conclusions:There are significant positive correlations between CHOL,LDL,TG/HDL and CRP with numbers of stenosed coronary artery(P＜0.05).There are significant positive correlations between HbAlc,CHOL and LDL/HDL with coronary angiography score.There are significant positive correlations between plasma HbAlc concentration,serum lipid concentration and CRP concentration.