| Objective:To investigate the expression of sesamin on cholesterol and serum intercellular adhesion molecule-lin atherosclerosis rabbits,and explore the effection of sesamin prevent atherosclerosis.Methods:1.Group:18 Japanese white rabbits were used.Rabbits fed normal diet were used as control group(n=6),and that fed high-cholesterol diet as atherosclerotic model group(n=6).The remained rabbits(n=6) were fed the high cholesterol diet containing sesamin(4mg/d,by stomach irrigating). 2.Model:Bovine serum albumin(250mg/kg) were used once by ear- edge intravenous injection to these rabbits fed high cholesterol diet at beginning of this study.3.Methods:The aortic fragments were cut and stained with hematoxylin to odserved the pathologic chang.Oxidase method was used to determine concentrations of total cholesterol(TC),triglycerides(TG),high-density lipoprotein(HDL) and low-density lipoprotein(LDL) at the time of 0,5th,8th week-end.ELISA method was used to determine serum inter-cellular adhesion molecule-1 of each group at the time of 8th week-end.Results:(1)The pathologic chang of arteria aorta endomembrane in sesamin group was singnificantly lighter than that in model group.(2)The TC,TG and LDL in sesamin group were significantly lower than that in model group (p＜0.01).(3)Serum intercellular adhesion molecule-1 in sesamin group was significantly lower than that in model group.Serum intercellular adhesion molecule-1 was positively associated with TC and LDL.Conclusions:(1)Sesamin effectively decreased the concentrations of TC,TG and LDL,reduced the lipid deposition area,which may relate to the anti-oxidative effection as well as the inhibition of ox-LDL synthesis. (2)Sesamin effectively decreased the serum intercellular adhesion molecule-1.Sesamin could inhibit intercellular adhesion and reduce inflammation reation.(3)Sesamin treatment was more effective on inhibiting atherosclerosis.Sesamin is potential to be one of green health products for economic primary prevention from atherosclerosis.
|
PDF Full Text Request