Study On Metabolic Syndrome And Sexual Hormone Concentrations In Perimenopausal And Postmenopausal Women

Objective: Metabolic syndrome (MS) is characterized by a combination of risk factors of cardiovascular disease. The aim of the study was to investigate the relationship between MS and sexual hormone alterations in perimenopausal and postmenopausal women.Methods: Total 287 relevant patients between 40 and 60 years old were randomly selected and divided into two groups: perimenopausal group (n=196) and postmenopausal group (n=91). For all the patients, height, weight, blood pressure, fasting blood glucose (FBG) and serum lipid were measured. For perimenopausal group, Serum FSH, LH, E₂ and T concentrations were measured by RIA on the 3rd day of menstrual cycle. For postmenopausal group, these items were measured at a random time. According to the standard of Chinese diabetes society (2004) for diagnosing metabolic syndrome, the patients were divided into two groups. The patients who had at least one of following diseases: obesities, high blood pressure, serum lipid disorder or diabetes were attributed to research group, and the rest to control group. The research group was again subdivided into MS group, obesity group, high blood pressure group, serum lipid disorder group and diabetes group. The differences on serum E₂, T concentrations and E₂/T rate were done between the research group and the control group were analyzed.Result:â‘ In postmenopausal group, serum E₂ and E₂/T levels were significantly lower in the MS group compared to the control group (P<0.05). But there was no significant difference in perimenopausal group.â‘¡In postmenopausal group, serum E₂ and E₂/T level were significantly lower in the serum lipid disorder group compared to the control group (P<0.05). But there was no significant difference in periraenopausal group.â‘¢In postmenopausal group, Serum E₂ and E₂,/T level were significantly lower, and T was significantly higher in the diabetes group compared to the control group (P<0.05). But there was no significant difference in perimenopausal group.â‘£There was significant difference in serum E₂/T between all MS groups and all control groups (P<0.05), but no significant difference in serum E₂ and T between two groups.⑤Serum E₂ and E₂/T were significantly lower in the MS group of postmenopausal group compared to the MS group of perimenopausal group (P<0.05). But there was no significant difference in serum T between two groups. ?There was no significant difference in serum E₂, T and E₂/T between obesity group and control group both in perimenopausal and postmenopausal women.Conclusion: The disorder of serum lipid and MS in postmenopausal women may be caused by the decline of serum estrogen. The disorder of blood sugar may be associated with both decreasing in serum estrogen level and increasing of serum testosterone level. The imbalance of estrogen and androgen may have the important impact in resulting MS.