The Clinical And Pathological Analysis Of Barrett Esophagus

Part I The Clinical and Pathological Analysis of Barrett EsophagusObjectives:To investigate the correlation among the clinical character, endoscopic classification and pathological character of Barrett esophagus (BE) diagnosed by endoscopy. Methods:Clinical character, endoscopic classification and pathological character were assessed in 184 BE patients diagnosed by endoscopy.Results:⑴most patients had typical symptoms of gastroesophageal reflux diseases (GERD); 37 patients had no symptoms.⑵Endoscopic classification included lamellar 128 cases, circumferential 43 cases and tongues 13 cases.⑶Columnar epithelium metaplasia were confirmed in 88 cases by the histopathology, intestinal metaplasia were confirmed in 46 of 88 cases and dysplasia in one case.⑷There are siginificantly difference in clinical manifestation of sour regurgitation between patients with or without columnar epithelium metaplasia,but no difference in clinical manifestation among patients with three different endoscopic classification..Conclusion:⑴There are siginificantly difference in clinical manifestation of sour regurgitation between patients with or without columnar epithelium metaplasia. Clinical manifestations are important for the diagnosis of BE.⑵There are no siginificantly difference in clinical manifestation among three different endoscopic classification.⑶Columnar epithelium metaplasia and intestinal metaplasia can occure in three types of endoscopic classification, Multi-point biopsy is necessary for diagnosis of BE.Part II Correlation between Quality of Life and Symptoms in the patients with Barrett EsophagusObjective:To investigate quality of life in patients with Barrett Esophagus (BE), And its relationship with symptoms.Methods:100 healthy subjects(HS), 134 patients with reflux esophagitis (RE) and 86 BE patients were included in this study .All subjects completed Short Form 36 Health survey Questionnaire(SF-36) and the symptoms were assessed.Results:Except the social functioning aspect (p=0.349), other healthy conceptions of life quality had significantly different among HS, BE, RE(P< 0.05.). Compared with HS, the score of life quality significantly decreased in patients with RE and BE. The scores of physiological functioning(P=0.000),Role-Physical and bodily pain (P=0.014)significantly decreased in BE patients compared with RE patients, but there were no difference in the score of psychological health(P=0.071)and general health(P=0.467) between BE and RE patients. There were negative correlation between life quality scores and symptoms score.Conclusions:⑴The quality of life decreases in both RE patients and BE patienets. It gets worse in BE patients⑵Symptoms are major factors that affect life quality in BE aptients,but the regurgitation is not the main factor .