The Effects Of Four Kinds Of Weight Relief Modality For Type 2 Diabetes Mellitus In Rats: A Random, Control Study

Objective:through contract experiment in random-selected groups and research into the effect of weight controlling and blood glucose controlling with 4 ways of losing weight of Gastric By-pass,Sleeve Gastrectomy,Gastric Lap-Band and Alimentary Control working on rats to find new effective treatment of Type 2 Diabetes Mellitus and explore the relationship between the control of blood glucose and decrease of body-weight and to analyze the principle of its function.Methods:to inject STZ into male SD rats to set objects,and randomly group the models into Gastric By-pass(GBP) group,Sleeve Gastrectomy (SG)group,Gastric Lap-Band(GLB) group and AC group and then execute Gastric By-pass,Sleeve Gastrectomy,Gastric Lap-Band and AC on them.Before and after the 1^st,4^th,12^th and 24^th weeks of the procedure, keeping trace of the changes of rats' weights,fasting blood glucose, glycosylated hemoglobin,GLP-land GIP.Result:10 rats in the GBP group remain after 24 weeks of operation;14 in the SG group remain,18 in the GLB group remain;12 in the AC group remain.The weights of rats in GBP group reduce greatly(t=-8.195, P＜0.05 );The fasting blood glucose of the rats in GBP group decreases after the 1^st week of operation,which has its statistic meaning(-4.828, P＜0.05),and it is also of statistic meaning that the glycosylated hemoglobin change after operation(t= -6.066,P＜0.05).The blood glucose of rats in SG,GLB,AC group decrease in 4^th week after operation,which has its meaning(P＜0.05) compared with that before operation.And it is also of statistic meaning that compared with that before operation the glycosylated hemoglobin change in 12^th week after operation(P＜0.05).There is no statistic meaning in the change of GLP- 1 and GIP in the rats in each phase(P＞0.05 )Conclusion:all these ways of reducing body-weight can reduce blood glucose of Type 2 Diabetes Mellitus rats with STZ,but the Gastric By-pass shows the most significant effect.There is no obvious relation between the decrease of blood glucose and the decrease of the rats' body-weights and the reduction of the amount of feeding.The decrease of blood glucose happens earlier than decrease of the rats' body-weights. The method of reducing the weight of Type 2 Diabetes Mellitus rats doesn't illustrate the effect of changing GLP-1 and GIP.Its functioning principle requires a further research to provide new theoretical proof for the extensive clinic operation and way of cure of Type 2 Diabetes Mellitus.