The Clinical Study Of Using Shixiaosan Concoction In The Treatment Of Dysmenorrhea Of The Blood-Stasis Syndrome

Dysmenorrhea refers to the syndrome of painful menstruation.It occurs in the lower abdomen and may also be felt in the hips,lower back,or thighs. Other symptoms may include nausea,vomiting,diarrhea,lightheadedness,or general aching.There are two types of dysmenorrhea.Primary dysmenorrhea is menstrual pain that's not a symptom of an underlying gynecologic disorder but related to the normal process of menstruation.Secondary dysmenorrhea is menstruation pain that's related to some kind of gynecologic disorder, such as ovarian cysts and endometriosis.Primary dysmenorrhea is prevalent in adolescents and at the onset within 6-12 months after menarche.The condition is thought to be caused by excessive levels of prostaglandins, hormones that make the uterus contract during menstruation and childbirth. The first line of treatment is usually with analgesic drug.Oral contraceptives may also help reduce the severity of the symptoms.However, these medications taken long-term can induce many unwanted side-effects. Chinese Medicine has its long history in its treatment,well-know for its effectiveness and minimal side-effects.Purpose:To investigate the therapeutic effect of shixiaosan concoction in the treatment of dysmenorrhea of the blood-stasis syndrome,and to explore its mechanism of action in relieving the syndrome.Method:1.A total of sixty patients were randomly selected from the out-patients department to participate in the study,and were divided into 2 groups, treatment and control.The former was treated with shixiaosan concoction and the latter was treated with guizhifulingwan concoction.One course of treatment was 3 months.2.The severity of dysmenorrhea was classified according to"The Guide to Clinical Research of New and Herbal Drugs".3.The therapeutic effect was assessed as per the"Guide to Therapeutic Effect Assessment"and that of the Chinese medical syndrome.4.Observed indices:the total effective rates of both groups,the before and after score of the Chinese medical syndrome,the level of pain after treatment,the Chinese medical syndrome score of the groups,the individual symptoms of the Chinese medical syndrome.5.Biostatical Analysis:Averages were expressed as(?)±s;the Chi-square test was used to analyze categorical data;the t-test was used to analyze measurable data.The SPSS 11.5 software was used to determine all the above.Results:1.The overall effective rates of the treatment and control groups were 86.6%and 76.6%,respectively.Their change after the treatment was significantly better than before(p＜0.05),which indicated that the treatment group had better results than the control group.2.The before and after Chinese medical syndrome score was significantly better(p＜0.05),which indicated that both groups were effective in treatment dysmenorrhea.However,the scores between the two groups were not significantly different after treatment.3.The level of pain significantly decreased after treatment.The treatment group had 30 patients,of which 8 were clinically recovered,13 were very effective,7 were effective and 2 were ineffective;a total effective rate of 93.3%.The control group also had 30 patients,of which 4 were clinically recovered,11 were very effective,10 were effective and 5 were ineffective;a total effective rate of 83.9%.The change in the groups were statically analyzed,found that the treatment group was more effective in lowering the level of pain than the control group(p＜0.05)4.The score of the Chinese medical syndrome also improved after treatment. The treatment group had 3 patients who were clinically recovered,14 who were very effective,7 who were effective and 1 who was ineffective;a total effective rate of 96.0%.The control group had 2 patients who were clinically recovered,7 who were very effective,10 who were effective and 4 who was ineffective;a total effective rate of 82.6%.The change between the groups was analyzed and found that the treatment group had significantly better scores in Chinese medical syndromes that the control group(p＜0.05).Conclusions:The use of shixiaosan concoction was effective in treatment dysmenorrhea of the blood-stasis syndrome.