| Background:Myltiple myeloma is a malignant proliferation of plasma cells,which are relatively highly differentiated and secrete a monoclonal immunoglobulin. Longterm treatment is with chemotherapy such as oral melphalan,an alkylating agent,or more aggressive regimens in younger patients such as hematopoietic stem cells transplantation,HSCT.Despite treatment,the 50%survival is about 2 years.Myeloma is predominantly a disease of old people,the age of onset between 50 to 60 years old,although it may arise at any time in adult life.Patients may become caught in a vicious spiral of hypercalcaemia,volume depletion and renal failure.Such patients may not receive chemotherapy well enough due to senior age,week body and combined diseases,for example cardiovascular disease.Therefore,they recover more slowly and are more subject to myelosuppression and infection.The effect is also affected by Minimal Residual Disease and multidrug resisistence.It has been making much progress on treating multiple myeloma with chemotherapy and tradional Chinese medicine,which is good at decreasing the side effect and improving the quality of life.Therefore,it is necessary to study the effect of combining traditional Chinese medicine with chemotherapy on treating multuple myeloma.Yi Shen Huo Xue Decoction is invented by Professor Liang Bing in Guangdong Provincial TCM Hospital.Recalling the issue through case studies,the focus of multiple myeloma of kidney deficiency and blood stasis,compare traditional Chinese medicine with chemotherapy and chemotherapy.Methods:1.Patients who received chemotherapy with traditional Chinese medicine Yi Shen Huo Xue Decoction are made to be treatment group while patients who only received chemotherapy are controlled group. 2.Pretherapy and after three course of treatment,the laboratory indicatrix is recorded:the proportion of plasma cells in bone marrow,bloodβ2-microglobulin,hemoglobin.3.The common adverse effect of the chemotherapy to multiple myeloma are recorded:nausea,vomiting,abdominal distension,constipation,loss of appetite,dry mouth,agrypnia.4.The changes of the clinical symptoms after treatment are recorded,the common clinical manifestations of multiple myeloma are bone pain, dizziness,vertigo,low back pain,tinnitus,limb numbness,a transient disturbance of consciousness,bleeding and so on.According to People's Republic of China Ministry of Health,Medical Secretary(1999) developed "clinical study of Chinese medicine guiding principles",the basic certification for kidney deficiency and blood stasis type,integrated with common symptoms of myeloma,to choose pain,dizziness,tinnitus, lunbago,bleeding,numb fingers.The extent of development were recorded before treatment and after treatment " -…+++",3 months after treatment to assess the basis grading the severity of symptoms.5.Records of the life evaluation after three course of treatment:Life evaluation is selected Sun Yan "medical oncology·quality of life of cancer patients score",the three signs which are importantindicators to MM patients: pain,appetite and mental state.Pain,primarily bone pain,is typical clinical manifestations for multiple myeolma,mainly due to the tumor cells of bone marrow damage caused.Therefore,the degree of pain is in response to a certain extent and the extent of the disease.Appetite are usually affected by chemotherapy drugs.Mental state after chemotherapy of patients not only reflects the degree of tolerance to chemotherapy,but also for the recovery after chemotherapy.These three indicators can be summed up in the description of multiple myeloma after chemotherapy in patients with the general living conditions,in part reflecting the quality of life of patients.6.Treatment effect:reference to Zhang's "blood disease diagnosis and efficacy of the standard".Effect of classification as follows:partial remission,progressive,null and void.Results:1.There is no significant statistical difference between treatment group and control group,P>0.05. 2.There is no significant statistical difference to the laboratory indicatrix after treatment between treatment group and control group,P>0.05.3.Treatment group has fewer adverse reactions,compared with the control group,P<0.05,statistical significant.4.There is significant statistical difference to the extent of clinical symptom improving after treatment between treatment group and control group, P<0.05.5.There is significant statistical difference to the life evaluation after treatment between treatment group and control group,P<0.05.Conclusions:Yi Shen Huo Xue Decoction with chemotherapy compared with chemotherapy alone,no significant changes in the laboratory,no significant improvement in efficacy,but patients with subjective symptoms and discomfort were significantly improved.Yi Shen Huo Xue Decoction can reduce the side effects of chemotherapy and improve patient tolerance to chemotherapy and improvethe quality of life of patients and promote the restoration.Whether Yi Shen Huo Xue Decoction can improve the precise effect of chemotherapy requires further large-scale clinical trials and pilot study to be confirmed. |
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