The Correlation With The Serum Hormone Estradiol And Progesterone Levels And Estrogen And Progesterone Receptors With The Disease Associated With Breast

In recent years, studies have shown that blood estrogen and progesterone and its metabolites or increase in estrogen and progesterone receptors led to the increase in breast diseases. Estrogen and progesterone receptor-positive breast cancer patients were given anti-estrogen therapy to improve the survival rate of 46%. Documents and reports, we found that in the clinical treatment of estrogen and progesterone receptor-negative advanced breast cancer, as well as benign proliferative breast disease to give anti-estrogen treatment as effective, in order to explore the mechanism of this phenomenon, we are of immunohistochemistry RIA, and serum testing of different types of breast disease (breast hyperplasia, breast fibroadenoma, breast cancer and papilloma) serum estrogen and progesterone levels and the organization of estrogen and progesterone receptor expression of benign and malignant breast disease research The estrogen and progesterone receptors and the relationship between the amount in order to breast disease prevention and treatment and provide a theoretical basis. Pre-operative blood samples taken from patients with breast diseases, menstrual cycle during the first 22d corpus luteum (the first day of the menstrual calculated on the day), fasting morning blood, blood per 5ml, RIA applications do estradiol and progesterone determined after surgery immunohistochemical detection of breast lesions in patients with the organization of estrogen and progesterone receptors. The results showed that:1. Benign breast disease of the blood estrogen and progesterone content and age-related, age <40-year-old group, estradiol levels in blood mammary gland hyperplasia in patients with a higher (P <0.05); age≥40-year-old female blood content of progesterone in breast cancer and breast fibroadenoma patients were higher (P <0.05);2. Breast cancer serum levels of estradiol and progesterone and estrogen receptor and progesterone receptor expression was significantly higher than other groups. Compared with the other groups were significantly different (P <0.05);3. Papilloma estrogen and progesterone receptor positive expression group was higher than that of breast hyperplasia, breast fibroids, and breast hyperplasia of the breast fibroadenoma group and control group were significantly different (P <0.05);4. Progesterone receptor expression in the normal group, the lowest rate of positive expression, and papilloma, the breast cancer group compared statistically significant difference P <0.05;5. Estrogen and progesterone receptor-negative breast cancer patients expression of serum estrogen and progesterone content level is still higher than that of other groups. This shows that the breast cancer group regardless of estrogen and progesterone receptor that is, ER, PR expression of positive or negative serum estrogen and progesterone levels high. The results suggest that:1. Benign breast disease in the blood of estrogen and progesterone content not only with age-related diseases associated with different;2. Estrogen increase in the incidence of breast cancer played an important and critical factors of estrogen and progesterone receptor-negative, but as long as serum estrogen and progesterone levels high, given anti-estrogen therapy can effectively alleviate the symptoms .The study explains the clinical treatment of estrogen and found that progesterone receptor-negative advanced breast cancer, as well as benign proliferative breast disease to give anti-estrogen treatment as effective mechanism. Anti-estrogen therapy, especially in patients with breast cancer, even if the expression of receptor-negative patients were also given to anti-estrogen therapy can effectively alleviate the condition, to extend the life of patients, the study of benign and malignant breast disease prevention and treatment has provided an important theoretical basis.