Evaluation Of Irbesartan In Vasovagal Syncope Treatment

BackgroundVasovagal syncope is a common and special type in many syncope types, it takes 70% of syncope without identify reasons. The pathogenesis of vasovagal syncope is not identify now, it maybe causes by tension of sympathetic nerve descenting and tension of vagus nerve raising up. In the part of treatment, in recent years, many scholars raise up many methods about treatment, roughly about three parts: common treatment, drug, pacemaker. The common drugs using in clinical are:β-block, ACEI,α-agonists, mineral, serotonin reuptake inhibitor. Now there are no reports about ARB using in treatment of vasovagal syncope, ARB is an antagonists of angiogenesis-Ⅱreceptor, what relationship between ARB and vasovagal syncope? Can ARB be used to treat vasovagal syncope? Because of theses questions we begin our research, choose irbesartan, to evaluate irbesartan in vasovagal syncope treatment.ObjectiveEvaluate irbesartan in vasovagal syncope treatment.Methods86 cases of VVS patients who had been positive in TTT were medicated with irbesartan 75mg daily for three months and followed up with TTT review.Results6 cases were quitted due to giddiness or unexplained reason, and other 80 VVS patients were not discovered faint and meanwhile 62.5% TTT were changed into negative after 3 months therapy. In 31 male patients, there are 20 patients who turn to negative, in 49 female patients, there are 30 patients who turn to negative, respectively with no significant changes (P>0.05). The mean values of blood pressure taken in lying position were compared between previous and following intervention, which were 124±7.24/71±6.38mmHg and 122±7.40/72±6.40mmHg respectively (P>0.05). The mean heart rates were 70.40±10.23/min and 71.35±9.29/min respectively with no significant changes (P>0.05). 10 patients whose heart rates were <60bpm, the heart rates were 55.10±3.11/min before rescue, and were 64.20±6.12/min after rescue, respectively with significant changes (P<0.001), so isbesartan can add the heat rates of patients.ConclusionIrbesartan was effective in treatment of VVS in which it didn't affect normal blood pressure and heart rate with safe and little side effects. To compared with normal drugs, Irbesartan has obviously ascendant. Meanwhile, we find that Irbesartan can add the heart rate about patients, whose basic heart rate is low. So Irbesartan is the new find in treatment of vasovagal syncope.