| Background:The rapidly increasing prevalence of obesity among children is one of the most challenging problems,which results in the early onset of adulthood chronic disease such as cardio-cerebrovascular disease,etc.Common carotid artery intima-media thickness(IMT) is the well-known marker of subclinical atheroscerosis and Could predict future cardio-cerebrovascular disease.It will be helpful to investigate the risk factors of cardio-cerebrovascular disease,and take interventions and preventions previously in attenuating the trend of rejuvenation of elderly chronic illness, reducing morbidity of cardio-cerebrovascular events.Objectives:The present study was to assess whether atherosclerosis had begun in obese childhood and adolescences,and to investigate risk factors which impact on common carotid artery IMT.Methods:A total of 62 obese subjects(group A) with at least one component of metabolic syndrome(MS) and 50 obese subjects(group B) without components of MS were enrolled.The controls(group C) were consisted of 32 healthy children and adolescents matching on age and gender.Body weight,waist circumference(WC), waist to hip ratio(WHR),systolic blood pressure(SBP),diastolic blood pressure(DBP), total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C), low'density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),fasting insulin(FINS) and common carotid IMT were meassured.Correlation analysis was used to analyze the the association between common carotid IMT and correlation factors.Stepwise multivariate linear regression analysis was used to explore the most important factors of incrseased common carotid IMT.Results:1 There was no statistical difference among three groups in the age and sex(χ~2 =0.696,P=0.706;F=2.173,P=0.118).2 Compared with group C,group A and B showed increased body weight,WC, WHR,BMI and SBP(P＜0.01),and group A showed higher DBP(P＜0.01) compared with group C;Group A had higher values of body weight,WC,BMI than group B.3 Compared with group C,group A and B showed increased TC,LDL-C,FINS, HOMA-IR and higher prevalence of fatty liver disease(P＜0.01),and group A showed higher TG,lower HDL-C(P＜0.01) compared with group C.Group A had higher values of TG,LDL-C,FINS,HOMA-IR and higher prevalence of fatty liver disease,lower value of HDL-C than the group B.4 The mean common carotid artery IMT were 0.72±0.10 mm(left),0.72±0.13 (right)(group A);0.67±0.09 mm(left),0.66±0.10(right)(group B);0.37±0.09 mm(left),0.37±0.09(right)(group C) respectively.There were significant differences among three groups(P＜0.05).5 WC,WHR,BMI,SBP,TG,TC,LDL-C,FINS,HOMA-IR and fatty liver were significantly positive associated with common carotid artery IMT;HDL-C was negative associated with IMT within all subjects.WHR,WC were significantly positive associated with BMI in a linear correlation analysis.6 BMI,WHR and TG were pronounced in the last regression equation in a stepwise multivariate linear regression analysis,the standard partial regression coefficients were 0.538,0.215 and 0.203 respectively(P＜0.01).Conclusions:Atherosclerosis has begun in obese childhood and adolescence,and this tendency was intensified by with the components of MS.Obesity especially central type and high TG may be the predictors of angiocardiopathy.
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